Reemerging of enterovirus 71 in Taiwan: The age impact on disease severity

研究成果: Article

29 引文 (Scopus)

摘要

Enterovirus 71 (EV71) infection commonly strike children under the age of 3 years, with an occasionally unfavorable outcome in children. This study was designed to explore the relationship between age and the severity of complications, which may associate with antibody-dependent enhancement (ADE) in EV71. All EV71-infected patients during the outbreak of 2008 were recruited. In total, 134 patients were enrolled and categorized into two age groups, 0-12 months (n=18) and ≥12 months (n=116). Pulmonary edema/hemorrhage more commonly occur in patients younger than 12 months. No difference in the occurrence of herpangina/hand-foot-and-mouth disease (HFMD), uncomplicated brainstem encephalitis (BE), or autonomic nervous system (ANS) dysregulation was noted between the two age groups. Patients with pulmonary edema/hemorrhage (11.9±14.7 months) were younger than patients with herpangina/HFMD (35.8±26.4 months) or ANS dysregulation (33.9± 20.9 months). Our findings are in agreement with the data regarding the outbreak in Taiwan, in which a decrease in age corresponded to an increase in disease severity with regard to central nervous system complications. A reduction of maternal antibodies to the subneutralizing level within 1 year of age may be associated with the ADE of the infection. This study could provide possible clinical significance with regard to ADE phenomena in young infants infected by EV71.

原文English
頁(從 - 到)1219-1224
頁數6
期刊European Journal of Clinical Microbiology and Infectious Diseases
31
發行號6
DOIs
出版狀態Published - 2012 六月 1

指紋

Enterovirus
Taiwan
Antibody-Dependent Enhancement
Herpangina
Hand, Foot and Mouth Disease
Autonomic Nervous System
Pulmonary Edema
Disease Outbreaks
Age Groups
Enterovirus Infections
Hemorrhage
Encephalitis
Brain Stem
Central Nervous System
Mothers
Antibodies
Infection

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases

引用此文

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title = "Reemerging of enterovirus 71 in Taiwan: The age impact on disease severity",
abstract = "Enterovirus 71 (EV71) infection commonly strike children under the age of 3 years, with an occasionally unfavorable outcome in children. This study was designed to explore the relationship between age and the severity of complications, which may associate with antibody-dependent enhancement (ADE) in EV71. All EV71-infected patients during the outbreak of 2008 were recruited. In total, 134 patients were enrolled and categorized into two age groups, 0-12 months (n=18) and ≥12 months (n=116). Pulmonary edema/hemorrhage more commonly occur in patients younger than 12 months. No difference in the occurrence of herpangina/hand-foot-and-mouth disease (HFMD), uncomplicated brainstem encephalitis (BE), or autonomic nervous system (ANS) dysregulation was noted between the two age groups. Patients with pulmonary edema/hemorrhage (11.9±14.7 months) were younger than patients with herpangina/HFMD (35.8±26.4 months) or ANS dysregulation (33.9± 20.9 months). Our findings are in agreement with the data regarding the outbreak in Taiwan, in which a decrease in age corresponded to an increase in disease severity with regard to central nervous system complications. A reduction of maternal antibodies to the subneutralizing level within 1 year of age may be associated with the ADE of the infection. This study could provide possible clinical significance with regard to ADE phenomena in young infants infected by EV71.",
author = "Shih-Min Wang and Tzong-Shiann Ho and Lin, {H. C.} and Lei, {H. Y.} and Jen-Ren Wang and Ching-Chuan Liu",
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AU - Wang, Jen-Ren

AU - Liu, Ching-Chuan

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