Regulation of the novel senescence pathway by SKP2 E3 ligase

Guocan Wang, Yuan Gao, Li Chen, Ying Jan Wang, Hui Kuan Lin

研究成果: Chapter

摘要

Cellular senescence, a stress response triggered by multiple stimuli, results in a form of irreversible cell cycle arrest that can serve as a critical barrier for cancer development. Various studies have demonstrated the critical role of ARF/p53 pathways in the induction of cellular senescence by activation of oncogenic pathways through overexpression of oncogenes, such as Ras, or by inactivation of tumor suppressor genes, such as PTEN. Recent studies also uncover novel ARF/p53-independent cellular senescence pathways in restricting tumorigenesis. Given that ARF/p53 pathways play an essential role in tumor suppression and are often inactivated in human cancers through defi ciency or mutations of ARF or p53, better understanding of these pathways governing the induction of senescence in human cancer will pave the ways for developing effective pro-senescence therapies. Thus, it’s important to screen current available drugs that stabilize p53 expression for the ability totarget possibility that these Arf-p53 dependent pathways or by developing novel inhibitors to target the Arf- p53 independent pathways.

原文English
主出版物標題Tumor Dormancy, Quiescence, and Senescence, Volume 2
主出版物子標題Aging, Cancer, and Noncancer Pathologies
發行者Springer Netherlands
頁面33-43
頁數11
ISBN(電子)9789400777262
ISBN(列印)9789400777255
DOIs
出版狀態Published - 2014 1月 1

All Science Journal Classification (ASJC) codes

  • 一般農業與生物科學
  • 一般生物化學,遺傳學和分子生物學
  • 一般醫學

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