摘要
This study investigated the characteristics of patients with different chronic kidney disease (CKD) stages according to various body mass index (BMI) categories and determined the influence of BMI in renal function deterioration. We conducted a multicenter, longitudinal cohort study based on the Epidemiology and Risk Factors Surveillance of CKD project (2008-2013) and National Health Insurance Research Database (2001-2013). A total of 7357 patients with CKD aged 20-85 years from 14 hospitals were included in the study. A higher male sex, diabetes mellitus (DM) and hypertension were noted among overweight and obese CKD patients, while more cancer prevalence was noted among underweight CKD patients. Charlson comorbidity index was significantly higher and correlated with BMI among late CKD patients. Patients with BMI < 18.5 kg/m2 exhibited non-significantly higher events of eGFR decline events in both early and late CKD stages than other BMI groups. BMI alone is not a determinant of CKD progression among our Taiwanese CKD patients. Obesity should be re-defined and body weight manipulation should be individualized in CKD patients.
| 原文 | English |
|---|---|
| 文章編號 | 6908 |
| 期刊 | Scientific reports |
| 卷 | 8 |
| 發行號 | 1 |
| DOIs | |
| 出版狀態 | Published - 2018 十二月 1 |
指紋
All Science Journal Classification (ASJC) codes
- General
引用此文
}
Relationship between body mass index and renal function deterioration among the Taiwanese chronic kidney disease population. / Chang, Tian Jong; Zheng, Cai Mei; Wu, Mei Yi; Chen, Tzu Ting; Wu, Yun Chun; Wu, Yi Lien; Lin, Hsin Ting; Zheng, Jing Quan; Chu, Nain Feng; Lin, Yu Me; Su, Sui Lung; Lu, Kuo Cheng; Chen, Jin Shuen; Sung, Fung Chang; Lee, Chien Te; Yang, Yu; Hwang, Shang Jyh; Wang, Ming Cheng; Hsu, Yung Ho; Chiou, Hung Yi; Kao, Senyeong; Lin, Yuh Feng.
於: Scientific reports, 卷 8, 編號 1, 6908, 01.12.2018.研究成果: Article
TY - JOUR
T1 - Relationship between body mass index and renal function deterioration among the Taiwanese chronic kidney disease population
AU - Chang, Tian Jong
AU - Zheng, Cai Mei
AU - Wu, Mei Yi
AU - Chen, Tzu Ting
AU - Wu, Yun Chun
AU - Wu, Yi Lien
AU - Lin, Hsin Ting
AU - Zheng, Jing Quan
AU - Chu, Nain Feng
AU - Lin, Yu Me
AU - Su, Sui Lung
AU - Lu, Kuo Cheng
AU - Chen, Jin Shuen
AU - Sung, Fung Chang
AU - Lee, Chien Te
AU - Yang, Yu
AU - Hwang, Shang Jyh
AU - Wang, Ming Cheng
AU - Hsu, Yung Ho
AU - Chiou, Hung Yi
AU - Kao, Senyeong
AU - Lin, Yuh Feng
PY - 2018/12/1
Y1 - 2018/12/1
N2 - This study investigated the characteristics of patients with different chronic kidney disease (CKD) stages according to various body mass index (BMI) categories and determined the influence of BMI in renal function deterioration. We conducted a multicenter, longitudinal cohort study based on the Epidemiology and Risk Factors Surveillance of CKD project (2008-2013) and National Health Insurance Research Database (2001-2013). A total of 7357 patients with CKD aged 20-85 years from 14 hospitals were included in the study. A higher male sex, diabetes mellitus (DM) and hypertension were noted among overweight and obese CKD patients, while more cancer prevalence was noted among underweight CKD patients. Charlson comorbidity index was significantly higher and correlated with BMI among late CKD patients. Patients with BMI < 18.5 kg/m2 exhibited non-significantly higher events of eGFR decline events in both early and late CKD stages than other BMI groups. BMI alone is not a determinant of CKD progression among our Taiwanese CKD patients. Obesity should be re-defined and body weight manipulation should be individualized in CKD patients.
AB - This study investigated the characteristics of patients with different chronic kidney disease (CKD) stages according to various body mass index (BMI) categories and determined the influence of BMI in renal function deterioration. We conducted a multicenter, longitudinal cohort study based on the Epidemiology and Risk Factors Surveillance of CKD project (2008-2013) and National Health Insurance Research Database (2001-2013). A total of 7357 patients with CKD aged 20-85 years from 14 hospitals were included in the study. A higher male sex, diabetes mellitus (DM) and hypertension were noted among overweight and obese CKD patients, while more cancer prevalence was noted among underweight CKD patients. Charlson comorbidity index was significantly higher and correlated with BMI among late CKD patients. Patients with BMI < 18.5 kg/m2 exhibited non-significantly higher events of eGFR decline events in both early and late CKD stages than other BMI groups. BMI alone is not a determinant of CKD progression among our Taiwanese CKD patients. Obesity should be re-defined and body weight manipulation should be individualized in CKD patients.
UR - http://www.scopus.com/inward/record.url?scp=85046681150&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85046681150&partnerID=8YFLogxK
U2 - 10.1038/s41598-018-24757-6
DO - 10.1038/s41598-018-24757-6
M3 - Article
C2 - 29720598
AN - SCOPUS:85046681150
VL - 8
JO - Scientific Reports
JF - Scientific Reports
SN - 2045-2322
IS - 1
M1 - 6908
ER -