Relationship between injury severity and serum tau protein levels in traumatic brain injured rats

Po Chou Liliang, Cheng Loong Liang, Kang Lu, Kuo Wei Wang, Hui Ching Weng, Ching Hua Hsieh, Yu Duan Tsai, Han Jung Chen

研究成果: Article同行評審

42 引文 斯高帕斯(Scopus)

摘要

Background: Although serum tau protein levels increase following TBI, the time course is unknown. The aim of the present study was to determine whether serum tau protein levels increased in both a severity-dependent and time-dependent manner in an experimental model of rat traumatic brain injury (TBI). Methods: A total of 24 Sprague-Dawley rats were subjected to varying grades of TBI using a contusion injury model on the right parietal cortex. Enzyme-linked Immunoabsorbent Assay (ELISA) analysis for serum was performed at 15. min pre-injury, 1, 6, 24, 48, and 168. h post-injury. Immunoblotting for serum tau protein, neurological evaluation and histological observation were also performed. Results: Tau protein levels rapidly increased after 1. h in both mild and severe TBI groups (p< 0.001), and declined after 6. h. In the sham-operated group, tau protein levels did not change significantly after TBI. Tau protein levels were severity-dependent at 1 and 6. h after TBI. The levels were higher in the severe TBI group than in the mild TBI group at 1. h (p< 0.001) and 6. h (p< 0.001). Conclusions: Serum tau protein levels were severity-dependent and time-dependent at 1 and 6. h after TBI. However, the serum tau protein may not be a useful marker 24. h after TBI.

原文English
頁(從 - 到)1205-1208
頁數4
期刊Resuscitation
81
發行號9
DOIs
出版狀態Published - 2010 9月

All Science Journal Classification (ASJC) codes

  • 急診醫學
  • 緊急護理
  • 心臟病學與心血管醫學

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