Renal fibrosis: Prediction from acute pyelonephritis focus volume measured at 99mTc dimercaptosuccinic acid SPECT

研究成果: Article同行評審

26 引文 斯高帕斯(Scopus)

摘要

PURPOSE: To evaluate whether acute pyelonephritis lesion volume derived from acute technetium 99m (99mTc) dimercaptosuccinic acid (DMSA) renal single photon emission computed tomographic (SPECT) images is predictive of the development of subsequent renal fibrosis. MATERIALS AND METHODS: Children with acute pyelonephritis underwent 99mTc DMSA renal SPECT during acute infection and 6-10 months later. At quantitative analysis, the volume of photopenic lesions and the ratio of radioactivity in the photopenic lesion to that in normal renal tissue were calculated. Sensitivity, specificity, and positive and negative predictive values were determined. RESULTS: Sixty-nine acute pyelonephritis foci in 44 children were analyzed. Thirtyseven (54%) of these lesions were normal on follow-up renal scans, while 32 (46%) developed scars. Significant differences in the photopenic lesion volume were found between the two groups (P < .001). When photopenic lesion volume indicated a positive diagnosis (≥4.6-cm3 lesion volume), sensitivity, specificity, positive predictive, and negative predictive values were 96.7%, 92.3%, 90.6%, and 97.3%, respectively. CONCLUSION: Quantitative analysis of acute DMSA renal SPECT findings is valuable in predicting renal fibrosis. The volume of an acute pyelonephritis lesion is useful in predicting the development of fibrosis.

原文English
頁(從 - 到)366-370
頁數5
期刊Radiology
221
發行號2
DOIs
出版狀態Published - 2001

All Science Journal Classification (ASJC) codes

  • 放射學、核子醫學和影像學

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