摘要
Background and aims: Renal dysfunction is a potent risk factor for cardiovascular diseases, including stroke. This study aimed to evaluate the impact of admission estimated glomerular filtration rate (eGFR) levels on short-term (1-month) and long-term (1-year) mortality in patients with acute ischemic stroke. Methods: From the Taiwan Stroke Registry data, we classified ischemic stroke patients, identified from April 2006 to December 2015, into 5 groups by eGFR at admission: ≥ 90, 60–89, 30–59, 15–29, and <15 mL/min/1.73 m2 or on dialysis. Risks of 1-month mortality and 1-year mortality after ischemic stroke were investigated by the eGFR level. Results: Among 52,732 ischemic stroke patients, 1480 died within one month. The 1-month mortality rate was over 5-fold greater in patients with eGFR <15 mL/min/1.73 m2 or dialysis than in patients with eGFR ≥90 mL/min/1.73 m2 (2.88 versus 0.56 per 1000 person-days). The adjusted hazard ratio (HR) of 1-month mortality increased from 1.31 (95% CI = 1.08–1.59) for patients with eGFR 60–89 mL/min/1.73 m2 to 2.33 (95% CI = 1.80–3.02) for patients with eGFR < 15 mL/min/1.73 m2 or on dialysis. 3226 patients died within one year. The adjusted HR of mortality increased from 1.38 (95% CI = 1.21–1.59) for patients with eGFR 60–89 mL/min/1.73 m2 to 2.60 (95% CI 2.18–3.10) for patients with eGFR < 15 mL/min/1.73 m2 or on dialysis, compared to patients with eGFR ≥ 90 mL/min/1.73 m2. Conclusions: After acute ischemic stroke, patients with reduced eGFR are at elevated risks of short-term and long-term deaths in a graded relationship.
| 原文 | English |
|---|---|
| 頁（從 - 到） | 288-293 |
| 頁數 | 6 |
| 期刊 | Atherosclerosis |
| 卷 | 269 |
| DOIs | |
| 出版狀態 | Published - 2018 2月 1 |
All Science Journal Classification (ASJC) codes
- 心臟病學與心血管醫學
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於: Atherosclerosis, 卷 269, 01.02.2018, p. 288-293.
研究成果: Article › 同行評審
TY - JOUR
T1 - Renal function is associated with 1-month and 1-year mortality in patients with ischemic stroke
AU - Wang, I. Kuan
AU - Liu, Chung Hsiang
AU - Yen, Tzung Hai
AU - Jeng, Jiann Shing
AU - Sung, Sheng Feng
AU - Huang, Pai Hao
AU - Li, Jie Yuan
AU - Sun, Yu
AU - Wei, Cheng Yu
AU - Lien, Li Ming
AU - Tsai, I. Ju
AU - Sung, Fung Chang
AU - Hsu, Chung Y.
AU - Liu, Chung Hsiang
AU - Tsai, Chon Haw
AU - Huang, Wei Shih
AU - Lu, Chung Ta
AU - Tsai, Tzung Chang
AU - Tseng, Chun Hung
AU - Lin, Kang Hsu
AU - Shyu, Woei Cherng
AU - Yang, Yu Wan
AU - Liu, Yen Liang
AU - Cho, Der Yang
AU - Chen, Chun Chung
AU - Tang, Sung Chun
AU - Tsai, Li Kai
AU - Yeh, Shin Joe
AU - Chen, Chih Hao
AU - Tsai, Hsin Hsi
AU - Chen, Han Jung
AU - Lu, Kan
AU - Hsu, Shih Pin
AU - Kuo, Hung Chang
AU - Tsou, Jung Chi
AU - Wang, Yan Tang
AU - Tai, Yi Cheng
AU - Hsieh, Meng Tsang
AU - Liliang, Po Chao
AU - Liang, Cheng Loong
AU - Wang, Hao Kuang
AU - Tsai, Yu Tun
AU - Wang, Kuo Wei
AU - Chen, Jui Sheng
AU - Chen, Po Yuan
AU - Wang, Yi Ching
AU - Sung, Pi Shan
AU - Hsieh, Han Chieh
AU - Su, Hui Chen
AU - Chiu, Hou Chang
AU - Chen, Wei Hung
AU - Bai, Chyi Huey
AU - Huang, Tzu Hsuan
AU - Lau, Chi Ieong
AU - Wu, Ya Ying
AU - Yeh, Hsu Ling
AU - Chang, Anna
AU - Lin, Ching Huang
AU - Yen, Cheng Chang
AU - Lin, Ruey Tay
AU - Khor, Gim Thean
AU - Chao, A. Ching
AU - Lin, Hsiu Fen
AU - Huang, Poyin
AU - Lin, Huey Juan
AU - Ke, Der Shin
AU - Chang, Chia Yu
AU - Yeh, Poh Shiow
AU - Lin, Kao Chang
AU - Cheng, Tain Junn
AU - Chou, Chih Ho
AU - Yang, Chun Ming
AU - Shen, Hsiu Chu
AU - Chen, An Chih
AU - Tsai, Shih Jei
AU - Lu, Tsong Ming
AU - Kung, Sheng Ling
AU - Lee, Mei Ju
AU - Chou, Hsi Hsien
AU - Chang, Wei Lun
AU - Chiu, Pai Yi
AU - Hsu, Min Hsien
AU - Chan, Po Chi
AU - Pan, Chau Hsiung
AU - Shoung, Hai Ming
AU - Lo, Yi Chen
AU - Wang, Fu Hwa
AU - Chang, Wei Chieh
AU - Lai, Ta Chang
AU - Yin, Jiu Haw
AU - Wang, Chung Jen
AU - Wang, Kai Chen
AU - Chen, Li Mei
AU - Denq, Jong Chyou
AU - Lu, Chien Jung
AU - Huang, Chieh Cheng
AU - Chan, Hoi Fong
AU - Lee, Siu Pak
AU - Sun, Ming Hui
AU - Ke, Li Ying
AU - Chen, Po Lin
AU - Lee, Yu Shan
AU - Ong, Cheung Ter
AU - Wu, Chi Shun
AU - Hsu, Yung Chu
AU - Su, Yu Hsiang
AU - Hung, Ling Chien
AU - Lee, Jiunn Tay
AU - Lin, Jiann Chyun
AU - Hsu, Yaw Don
AU - Peng, Giia Sheun
AU - Hsu, Chang Hung
AU - Lin, Chun Chieh
AU - Yen, Che Hung
AU - Cheng, Chun An
AU - Sung, Yueh Feng
AU - Chen, Yuan Liang
AU - Lien, Ming Tung
AU - Liu, Chia Chen
AU - Yang, Fu Chi
AU - Wu, Yi Chung
AU - Tso, An Chen
AU - Lai, Yu Hua
AU - Chiang, Chun I.
AU - Tsai, Chia Kuang
AU - Liu, Meng Ta
AU - Lin, Ying Che
AU - Chiang, Tsuey Ru
AU - Liao, Pin Wen
AU - Lee, Mei Ching
AU - Chen, Jen Tse
AU - Lie, Sian King
AU - Sun, Mu Chien
AU - Hsiao, Pi Ju
AU - Chen, Wei Liang
AU - Chen, Ta Cheng
AU - Chang, Chen Shu
AU - Lai, Chien Hsu
AU - Chuang, Chieh Sen
AU - Chen, Yen Yu
AU - Lin, Shinn Kuang
AU - Su, Yu Chin
AU - Shiao, Jen Lun
AU - Yang, Fu Yi
AU - Liu, Chih Yang
AU - Chiang, Han Lin
AU - Chen, Guei Chiuan
AU - Hsu, Po Jen
AU - Lin, I. sheng
AU - Chien, Chung Hsien
AU - Chang, Yang Chuang
AU - Chen, Ping Kun
AU - Hsiao, Yu Jen
AU - Fang, Chen Wen
AU - Chen, Yu Wei
AU - Lee, Kuo Ying
AU - Lin, Yun Yu
AU - Li, Chen Hua
AU - Tsai, Hui Fen
AU - Hsieh, Chuan Fa
AU - Yang, Chih Dong
AU - Liaw, Shiumn Jen
AU - Liao, How Chin
AU - Wu, Ling Li
AU - Hsieh, Liang Po
AU - Lee, Yong Hui
AU - Chen, Chung Wen
AU - Hsu, Chih Shan
AU - Jhih, Ye Jian
AU - Zhuang, Hao Yu
AU - Pan, Yan Hong
AU - Shih, Shin An
AU - Chen, Chin I.
AU - Sung, Jia Ying
AU - Weng, Hsing Yu
AU - Teng, Hao Wen
AU - Lee, Jing Er
AU - Huang, Chih Shan
AU - Chao, Shu Ping
AU - Yuan, Rey Yue
AU - Sheu, Jau Jiuan
AU - Yu, Jia Ming
AU - Ho, Chun Sum
AU - Lin, Ting Chun
AU - Yu, Shih Chieh
AU - Chen, Jiunn Rong
AU - Tsai, Song Yen
AU - Wei, Cheng Yu
AU - Hung, Chao Hsien
AU - Lee, Chia Fang
AU - Yang, Sheng Kung
AU - Chen, Chih Lin
AU - Lin, Wei
AU - Tseng, Hung Pin
AU - Lin, Chun Liang
AU - Lin, Hung Chih
AU - Chen, Pi Tzu
AU - Hu, Chaur Jong
AU - Chan, Lung
AU - Chi, Nai Fang
AU - Chern, Chang Ming
AU - Lin, Chun Jen
AU - Wang, Shuu Jiun
AU - Hsu, Li Chi
AU - Wong, Wen Jang
AU - Lee, I. Hui
AU - Yen, Der Jen
AU - Tsai, Ching Piao
AU - Kwan, Shang Yeong
AU - Soong, Bing Wen
AU - Chen, Shih Pin
AU - Liao, Kwong Kum
AU - Lin, Kung Ping
AU - Chen, Chien
AU - Shan, Din E.
AU - Fuh, Jong Ling
AU - Wang, Pei Ning
AU - Lee, Yi Chung
AU - Yu, Yu Hsiang
AU - Huang, Hui Chi
AU - Tsai, Jui Yao
AU - Wu, Ming Hsiu
AU - Chiang, Szu Yi
AU - Wang, Chiung Yao
AU - Hsu, Ming Chin
AU - Yeh, Po Yen
AU - Wang, Ko Yi
AU - Chen, Tsang Shan
AU - Hsieh, Cheng Yang
AU - Chen, Wei Fen
AU - Yip, Ping Keung
AU - Wang, Vinchi
AU - Tsai, Chung Fen
AU - Chen, Chao Ching
AU - Liu, Yi Chien
AU - Chen, Shao Yuan
AU - Zhao, Zi Hao
AU - Wei, Zhi Peng
AU - Wu, Shey Lin
AU - Liu, Ching Kuan
AU - Lin, Ryh Huei
AU - Chu, Ching Hua
AU - Yan, Sui Hing
AU - Hsiao, Sheng Huang
AU - Yip, Bak Sau
AU - Tsai, Pei Chun
AU - Chou, Ping Chen
AU - Kuo, Tsam Ming
AU - Chiu, Yi Pin
AU - Tsai, Kun Chang
AU - Liao, Yi Sheng
AU - Tsai, Ming Jun
AU - Kao, Hsin Yi
N1 - Funding Information: The present study was supported by the research laboratory of pediatrics, Children's Hospital of China Medical University ( DMR-105-041 ), China Medical University Hospital ( DMR-106-025 and DMR-107-026 ), Taiwan Ministry of Health and Welfare Clinical Trial and Research Center of Excellence ( MOHW106-TDU-B-212-113004 ), Academia Sinica Taiwan Biobank, Stroke Biosignature Project ( BM10601010036 ); Taiwan Clinical Trial Consortium for Stroke ( MOST 106-2321-B-039-005 ); Tseng-Lien Lin Foundation, Taichung, Taiwan ; Taiwan Brain Disease Foundation, Taipei, Taiwan ; and Katsuzo and Kiyo Aoshima Memorial Funds, Japan . Publisher Copyright: © 2017 Elsevier B.V.
PY - 2018/2/1
Y1 - 2018/2/1
N2 - Background and aims: Renal dysfunction is a potent risk factor for cardiovascular diseases, including stroke. This study aimed to evaluate the impact of admission estimated glomerular filtration rate (eGFR) levels on short-term (1-month) and long-term (1-year) mortality in patients with acute ischemic stroke. Methods: From the Taiwan Stroke Registry data, we classified ischemic stroke patients, identified from April 2006 to December 2015, into 5 groups by eGFR at admission: ≥ 90, 60–89, 30–59, 15–29, and <15 mL/min/1.73 m2 or on dialysis. Risks of 1-month mortality and 1-year mortality after ischemic stroke were investigated by the eGFR level. Results: Among 52,732 ischemic stroke patients, 1480 died within one month. The 1-month mortality rate was over 5-fold greater in patients with eGFR <15 mL/min/1.73 m2 or dialysis than in patients with eGFR ≥90 mL/min/1.73 m2 (2.88 versus 0.56 per 1000 person-days). The adjusted hazard ratio (HR) of 1-month mortality increased from 1.31 (95% CI = 1.08–1.59) for patients with eGFR 60–89 mL/min/1.73 m2 to 2.33 (95% CI = 1.80–3.02) for patients with eGFR < 15 mL/min/1.73 m2 or on dialysis. 3226 patients died within one year. The adjusted HR of mortality increased from 1.38 (95% CI = 1.21–1.59) for patients with eGFR 60–89 mL/min/1.73 m2 to 2.60 (95% CI 2.18–3.10) for patients with eGFR < 15 mL/min/1.73 m2 or on dialysis, compared to patients with eGFR ≥ 90 mL/min/1.73 m2. Conclusions: After acute ischemic stroke, patients with reduced eGFR are at elevated risks of short-term and long-term deaths in a graded relationship.
AB - Background and aims: Renal dysfunction is a potent risk factor for cardiovascular diseases, including stroke. This study aimed to evaluate the impact of admission estimated glomerular filtration rate (eGFR) levels on short-term (1-month) and long-term (1-year) mortality in patients with acute ischemic stroke. Methods: From the Taiwan Stroke Registry data, we classified ischemic stroke patients, identified from April 2006 to December 2015, into 5 groups by eGFR at admission: ≥ 90, 60–89, 30–59, 15–29, and <15 mL/min/1.73 m2 or on dialysis. Risks of 1-month mortality and 1-year mortality after ischemic stroke were investigated by the eGFR level. Results: Among 52,732 ischemic stroke patients, 1480 died within one month. The 1-month mortality rate was over 5-fold greater in patients with eGFR <15 mL/min/1.73 m2 or dialysis than in patients with eGFR ≥90 mL/min/1.73 m2 (2.88 versus 0.56 per 1000 person-days). The adjusted hazard ratio (HR) of 1-month mortality increased from 1.31 (95% CI = 1.08–1.59) for patients with eGFR 60–89 mL/min/1.73 m2 to 2.33 (95% CI = 1.80–3.02) for patients with eGFR < 15 mL/min/1.73 m2 or on dialysis. 3226 patients died within one year. The adjusted HR of mortality increased from 1.38 (95% CI = 1.21–1.59) for patients with eGFR 60–89 mL/min/1.73 m2 to 2.60 (95% CI 2.18–3.10) for patients with eGFR < 15 mL/min/1.73 m2 or on dialysis, compared to patients with eGFR ≥ 90 mL/min/1.73 m2. Conclusions: After acute ischemic stroke, patients with reduced eGFR are at elevated risks of short-term and long-term deaths in a graded relationship.
UR - http://www.scopus.com/inward/record.url?scp=85039456839&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85039456839&partnerID=8YFLogxK
U2 - 10.1016/j.atherosclerosis.2017.11.029
DO - 10.1016/j.atherosclerosis.2017.11.029
M3 - Article
C2 - 29254692
AN - SCOPUS:85039456839
SN - 0021-9150
VL - 269
SP - 288
EP - 293
JO - Atherosclerosis
JF - Atherosclerosis
ER -