Reovirus delays diabetes onset but does not prevent insulitis in nonobese diabetic mice

J. Denise Wetzel, Erik S. Barton, James D. Chappell, Geoffrey S. Baer, Michelle Mochow-Grundy, Steven E. Rodgers, Yu Shyr, Alvin C. Powers, James W. Thomas, Terence S. Dermody

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16 引文 斯高帕斯(Scopus)

摘要

Mice infected with reovirus develop abnormalities in glucose homeostasis. Reovirus strain type 3 Abney (T3A) was capable of systemic infection of nonobese diabetic (NOD) mice, an experimental model of autoimmune diabetes. Reovirus antigen was detected in pancreatic islets of T3A-infected mice, and primary cultures of pancreatic islets from NOD mice supported T3A growth. Significantly fewer T3A-infected animals compared to uninfected controls developed diabetes. However, despite the alteration in diabetes penetrance, insulitis was evident in T3A-infected mice. These results suggest that viral infection of NOD mice alters autoimmune responses to β-cell antigens and thereby delays development of diabetes.

原文English
頁(從 - 到)3078-3082
頁數5
期刊Journal of Virology
80
發行號6
DOIs
出版狀態Published - 2006 三月

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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