TY - JOUR
T1 - Repetitive sequence elements in an initiation locus of the amplified dihydrofolate reductase domain in CHO cells
AU - Leu, Tzeng Horng
AU - Anachkova, Boyka
AU - Hamlin, Joyce L.
N1 - Funding Information:
We thank William R. Pearson for helping us with the computer analysis, and our technicians, Kevin Cox and Carlton White, for expert and cheerful assistance. This work was supported by grants from the NIH and the American Cancer Society to J.L.H.
PY - 1990/7
Y1 - 1990/7
N2 - We have previously demonstrated that one of the replication initiation loci in the dihydrofolate reductase (DHFR) domain of Chinese hamster cells contains a repeated sequence that is enriched in the early-replicating fraction of the Chinese hamster genome. Here we present the sequence of the initiation locus, identify the relevant repeated element, and show that, while this element is enriched in early-replicating DNA, its synthesis is not confined to early S.
AB - We have previously demonstrated that one of the replication initiation loci in the dihydrofolate reductase (DHFR) domain of Chinese hamster cells contains a repeated sequence that is enriched in the early-replicating fraction of the Chinese hamster genome. Here we present the sequence of the initiation locus, identify the relevant repeated element, and show that, while this element is enriched in early-replicating DNA, its synthesis is not confined to early S.
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U2 - 10.1016/0888-7543(90)90178-W
DO - 10.1016/0888-7543(90)90178-W
M3 - Article
C2 - 2365359
AN - SCOPUS:0025040042
SN - 0888-7543
VL - 7
SP - 428
EP - 433
JO - Genomics
JF - Genomics
IS - 3
ER -