Review of Dscam-mediated immunity in shrimp and other arthropods

Tze Hann Ng, Yi An Chiang, Ying Chun Yeh, Han Ching Wang

研究成果: Review article同行評審

46 引文 斯高帕斯(Scopus)

摘要

Although true adaptive immunity is only found in vertebrates, there is increasing evidence that shrimp and other arthropods exhibit immune specificity and immune memory. The invertebrate immune response is now called "innate immunity with specificity" or "immune priming", and its underlying mechanisms are still unclear. However, while vertebrate antibodies have no invertebrate homolog, the Down syndrome cell adhesion molecule (Dscam), which is a hypervariable protein created by alternative splicing, can function as a pathogen-specific recognizing molecule in arthropods. Here we review our current understanding of the Dscam-mediated immune responses in arthropods, especially in shrimp, and show that Dscam may be involved in both general innate immunity and the pathogen-specific immune response.

原文English
頁(從 - 到)129-138
頁數10
期刊Developmental and Comparative Immunology
46
發行號2
DOIs
出版狀態Published - 2014 十月

All Science Journal Classification (ASJC) codes

  • Immunology
  • Developmental Biology

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