Ribavirin enhances interferon signaling via stimulation of mTOR and p53 activities

Wen Cheng Su, Wei Liang Liu, Ching Wei Cheng, Yu Bin Chou, Ko Hsuan Hung, Wen Hung Huang, Chao Liang Wu, Yuan Tsung Li, Ai Li Shiau, Ming Yang Lai

研究成果: Article同行評審

20 引文 斯高帕斯(Scopus)

摘要

Cellular mechanisms involving the enhancement of interferon (IFN) signaling by ribavirin remain poorly understood. Here, we identified a novel role of ribavirin in the communication between p53 and the mammalian target of rapamycin (mTOR) signaling. Ribavirin activates p53 by stimulating mTOR and promoting the interaction between mTOR and p53. Activated p53 stimulates the transcription of IFN regulatory factor 9 and subsequently enhances IFN signaling. Furthermore, ribavirin-induced activation of mTOR and p53 enhances IFN-dependent signaling for the IFN-α/ribavirin combined treatment. We conclude that ribavirin enhances activities of mTOR and p53, which may account for its antiviral and antitumor effects. Structured summary: MINT-7222801:. mTOR (uniprotkb:P42345) physically interacts (MI:0914) with raptor (uniprotkb:Q8N122) by anti bait coimmunoprecipitation (MI:0006). MINT-7222793:. mTOR (uniprotkb:P42345) physically interacts (MI:0914) with RICTOR (uniprotkb:Q8N6M7) by anti bait coimmunoprecipitation (MI:0006). MINT-7222784:. mTOR (uniprotkb:P42345) physically interacts (MI:0914) with P53 (uniprotkb:P04637) by anti bait coimmunoprecipitation (MI:0006).

原文English
頁(從 - 到)2793-2798
頁數6
期刊FEBS Letters
583
發行號17
DOIs
出版狀態Published - 2009 九月 3

All Science Journal Classification (ASJC) codes

  • 生物物理學
  • 結構生物學
  • 生物化學
  • 分子生物學
  • 遺傳學
  • 細胞生物學

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