TY - JOUR
T1 - Ribavirin reduces mortality in enterovirus 71-infected mice by decreasing viral replication
AU - Li, Zhao Hong
AU - Li, Chien Ming
AU - Ling, Pin
AU - Shen, Fang Hsiu
AU - Chen, Shih Heng
AU - Liu, Ching Chuan
AU - Yu, Chun Keung
AU - Chen, Shun Hua
N1 - Funding Information:
Received 23 August 2007; accepted 6 September 2007; electronically published 15 February 2008. Potential conflicts of interest: none reported. Presented in part: Pasteur/NHRI/CDC Symposium on Re-Emerging Virus Infections, Tainan, Taiwan, 1 September 2006 (abstract POS-17). Financial support: National Health Research Institute, Department of Health, Republic of China (grant NHRI-EX95–9530NI). Reprints or correspondence: Dr. Shun-Hua Chen, Dept. of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan 70101, Republic of China ([email protected]).
PY - 2008/3/15
Y1 - 2008/3/15
N2 - Enterovirus 71 (EV71) causes fatal encephalitis in young children. However, there is no effective antiviral drug available for infected patients. Ribavirin is currently used for the treatment of several RNA virus infections clinically, so its anti-EV71 efficacy was evaluated. In vitro results showed that ribavirin effectively reduced the viral yields (with an IC50 of 65 μg/mL) and virus-induced cytopathic effect in human and mouse cell lines. In vivo results showed that ribavirin reduced the mortality, morbidity, and subsequent paralysis sequelae in infected mice by decreasing viral loads in tissues. Thus, ribavirin could be a potential anti-EV71 drug.
AB - Enterovirus 71 (EV71) causes fatal encephalitis in young children. However, there is no effective antiviral drug available for infected patients. Ribavirin is currently used for the treatment of several RNA virus infections clinically, so its anti-EV71 efficacy was evaluated. In vitro results showed that ribavirin effectively reduced the viral yields (with an IC50 of 65 μg/mL) and virus-induced cytopathic effect in human and mouse cell lines. In vivo results showed that ribavirin reduced the mortality, morbidity, and subsequent paralysis sequelae in infected mice by decreasing viral loads in tissues. Thus, ribavirin could be a potential anti-EV71 drug.
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U2 - 10.1086/527326
DO - 10.1086/527326
M3 - Article
C2 - 18279075
AN - SCOPUS:40949089777
SN - 0022-1899
VL - 197
SP - 854
EP - 857
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 6
ER -