Ripple structure-generated hybrid electrokinetics for on-chip mixing and separating of functionalized beads

I. Fang Cheng, Sheng Chuan Chiang, Cheng Che Chung, Trai Ming Yeh, Hsien Chang Chang

研究成果: Article同行評審

6 引文 斯高帕斯(Scopus)

摘要

We present an electrokinetics-based microfluidic platform that is capable of on-chip manipulating, mixing, and separating microparticles through adjusting the interrelated magnitudes of dielectrophoresis and AC electroosmosis. Hybrid electrokinetic phenomenon is generated from an electric field-induced micro-ripple structure made of ultraviolet-curable glue. Size-dependent particle separation and selective removal over the ripple structure is demonstrated successfully. Varying the waveform from sine-wave to square-wave allows generating a fluid convection at specific positions to mix the antibody-functionalized beads and antigen. Potential application in the bead-based immunoassay was also demonstrated for immuno-reaction and subsequently separating the bead-bead aggregate and non-binding beads on-chip.

原文English
文章編號061102
期刊Biomicrofluidics
8
發行號6
DOIs
出版狀態Published - 2014 十二月 30

All Science Journal Classification (ASJC) codes

  • 生物醫學工程
  • 材料科學(全部)
  • 凝聚態物理學
  • 流體流動和轉移過程
  • 膠體和表面化學

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