Risk factors for pancreatic fistula grade C after pancreatoduodenectomy: A large prospective, multicenter Japan-Taiwan collaboration study

Seiko Hirono, Toshio Shimokawa, Yuichi Nagakawa, Yi Ming Shyr, Manabu Kawai, Ippei Matsumoto, Sohei Satoi, Hideyuki Yoshitomi, Takehiro Okabayashi, Fuyuhiko Motoi, Ryosuke Amano, Yoshiaki Murakami, Satoshi Hirano, Kazuyuki Kawamoto, Shoji Nakamori, Yan Shen Shan, Shinjiro Kobayashi, Hiroyuki Nitta, Hiroyoshi Matsukawa, Kazuhisa UchiyamaChih Po Hsu, Chie Kitami, Masakazu Yamamoto, Tsann Long Hwang, Hiroki Yamaue

研究成果: Article同行評審

5 引文 斯高帕斯(Scopus)

摘要

Background/Purpose: Grade C postoperative pancreatic fistula (POPF), as defined by International Study Group of Pancreatic Fistula (ISGPF), is the most life-threatening complication after pancreatoduodenectomy (PD). This study aims to evaluate risk factors for Grade C POPF after PD. Methods: This is a prospective, multicenter study based in Japan and Taiwan. Between December 2014 and May 2017, 3022 patients were enrolled in this study and 2762 patients were analyzed. We analyzed risk factors of Grade C POPF based on the updated 2016 ISGPF scheme (organ failure, reoperation, and/or death). Results: Among 2762 patients, 46 patients (1.7%) developed Grade C POPF after PD. The mortality rate of the 46 patients with Grade C POPF was 37.0%. On the multivariate analysis, six independent risk factors for Grade C POPF were found; BMI ≥ 25.0 kg/m2, chronic steroid use, preoperative serum albumin <3.0 mg/dL, soft pancreas, operative time ≥480 minutes, and intraoperative transfusion. The c-statistic of our risk scoring model for Grade C POPF using these risk factors was 0.77. The score was significantly higher in Grade C POPF than in Grade B POPF (P <.001) or none/biochemical leak (P <.001). Conclusions: This prospective study showed risk factors for Grade C POPF after PD.

原文English
頁(從 - 到)622-631
頁數10
期刊Journal of Hepato-Biliary-Pancreatic Sciences
27
發行號9
DOIs
出版狀態Published - 2020 九月 1

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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