TY - JOUR
T1 - Risk of incident dementia in late-life depression treated with antidepressants
T2 - A nationwide population cohort study
AU - Su, Jian An
AU - Chang, Chih Cheng
AU - Yang, Yao Hsu
AU - Chen, Ko Jung
AU - Li, Yueh Ping
AU - Lin, Chung Ying
N1 - Funding Information:
The authors thank the Health Information and Epidemiology Laboratory at the Chiayi Branch of Chang Gung Memorial Hospital for its assistance in data analysis. Wallace Academic Editing edited the manuscript. The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The research was supported by grant CFRPG6J0011 from Chang Gung Memorial Hospital.
Funding Information:
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The research was supported by grant CFRPG6J0011 from Chang Gung Memorial Hospital.
Publisher Copyright:
© The Author(s) 2020.
PY - 2020/10/1
Y1 - 2020/10/1
N2 - Background: Antidepressants are frequently used to treat depression in patients with dementia. In addition, late-life depression is associated with the incidence of subsequent cognitive impairment or dementia. However, the association between exposure to antidepressants in late-life depression and the development of incident dementia remains understudied. Methods: Through a population-based retrospective cohort design, data were extracted from the Taiwan National Health Insurance Research Dataset of medical claims registered from 1998–2013. We collected data of individuals who had received a new diagnosis of depression between 2000 and 2007. We excluded those who received a diagnosis of depression and were given antidepressants before 2000 and those younger than 60 years. The primary outcome was the occurrence of incident dementia. The time from the prescription of antidepressants or the diagnosis of depression until the outcome or the end of 2013 was calculated as the time to event. A total of 563,918 cases were included and were divided into either antidepressant users or antidepressant nonusers. Cox proportional hazards models were used to calculate the hazard ratio and 95% confidence interval. Results: Exposure to antidepressants did not increase the risk of dementia in patients with late-life depression at either a low exposure dosage (hazard ratio: 1.06, 95% confidence interval: 0.91–1.23) or a high exposure dosage (hazard ratio: 1.07, 95% confidence interval: 0.95–1.20). To confirm the validity of our results, we performed a sensitivity analysis and subgroup analysis, and the post-hoc results were consistent with the main results. Conclusion: Antidepressants did not increase the risk of incident dementia in patients with late-life depression.
AB - Background: Antidepressants are frequently used to treat depression in patients with dementia. In addition, late-life depression is associated with the incidence of subsequent cognitive impairment or dementia. However, the association between exposure to antidepressants in late-life depression and the development of incident dementia remains understudied. Methods: Through a population-based retrospective cohort design, data were extracted from the Taiwan National Health Insurance Research Dataset of medical claims registered from 1998–2013. We collected data of individuals who had received a new diagnosis of depression between 2000 and 2007. We excluded those who received a diagnosis of depression and were given antidepressants before 2000 and those younger than 60 years. The primary outcome was the occurrence of incident dementia. The time from the prescription of antidepressants or the diagnosis of depression until the outcome or the end of 2013 was calculated as the time to event. A total of 563,918 cases were included and were divided into either antidepressant users or antidepressant nonusers. Cox proportional hazards models were used to calculate the hazard ratio and 95% confidence interval. Results: Exposure to antidepressants did not increase the risk of dementia in patients with late-life depression at either a low exposure dosage (hazard ratio: 1.06, 95% confidence interval: 0.91–1.23) or a high exposure dosage (hazard ratio: 1.07, 95% confidence interval: 0.95–1.20). To confirm the validity of our results, we performed a sensitivity analysis and subgroup analysis, and the post-hoc results were consistent with the main results. Conclusion: Antidepressants did not increase the risk of incident dementia in patients with late-life depression.
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U2 - 10.1177/0269881120944152
DO - 10.1177/0269881120944152
M3 - Article
C2 - 32847467
AN - SCOPUS:85089984983
SN - 0269-8811
VL - 34
SP - 1134
EP - 1142
JO - Journal of Psychopharmacology
JF - Journal of Psychopharmacology
IS - 10
ER -