@article{56c2d5492fb24e3cb312c7e40861babc,
title = "Risk of sepsis among patients with COPD treated with fixed combinations of inhaled corticosteroids and long-acting Beta2 agonists",
abstract = "This study aimed to compare the effect of budesonide/formoterol and fluticasone/salmeterol on the risk and outcomes of sepsis in COPD patients. We conducted this study using the Taiwan National Health Insurance Research Database. We included COPD patients prescribed with budesonide/formoterol or fluticasone/salmeterol between 2004 and 2011. Outcomes including sepsis and mortality were measured. 10,267 COPD patients who received fluticasone/salmeterol and 6,844 patients who received budesonide/formoterol were enrolled into this study and then subsequence were adjusted by propensity score weighting. The incidence of sepsis was 5.74 and 4.99 per 100 person-years for the patients receiving fluticasone/salmeterol and budesonide/formoterol, respectively. Fluticasone/salmeterol was associated with higher risk of sepsis (aHR, 1.15; 95%CI, 1.07-1.24) and septic shock (aHR, 1.14; 95%CI, 1.01-1.29) than budesonide/formoterol. Besides, fluticasone/salmeterol was associated with higher risk of death (aHR, 1.090; 95%CI, 1.01-1.18) than budesonide/formoterol. Patients receiving fluticasone/salmeterol had a significant higher risk of sepsis related respiratory organ dysfunction, lower respiratory tract infection, genitourinary tract infection, bacteremia and skin infection. In conclusion, long-term treatment with budesonide/formoterol was associated with lower rates of sepsis and deaths than fluticasone/salmeterol in patients with COPD.",
author = "{On the behalf of Taiwan Clinical Trial Consortium for Respiratory Diseases (TCORE)} and Wang, {Cheng Yi} and Lin, {You Shuei} and Wang, {Ya Hui} and Lai, {Chih Cheng} and Wang, {Hao Chien} and Likwang Chen and Yu, {Chong Jen} and Yu, {Chong Jen} and Wang, {Hao Chien} and Perng, {Diahn Warng} and Cheng, {Shih Lung} and Hsu, {Jeng Yuan} and Hsu, {Wu Huei} and Tsai, {Ying Huang} and Hsiue, {Tzuen Ren} and Lin, {Meng Chih} and Lin, {Hen I.} and Wang, {Cheng Yi} and Chang, {Yeun Chung} and Yang, {Ueng Cheng} and Chen, {Chung Ming} and Lin, {Cing Syong} and Likwang Chen and Wei, {Yu Feng} and Chong, {Inn Wen} and Chen, {Chung Yu}",
note = "Funding Information: Taiwan Clinical Trial Consortium for Respiratory Diseases (TCORE) includes Chong-Jen Yu, MD, PhD, (NTUH, Director of Coordinating Center and Core PI of Committee); Hao-Chien Wang, MD, PhD (NTUH, PI of Committee), Diahn-Warng Perng, MD, PhD (Taipei Veterans General Hospital, PI of Committee), Shih-Lung Cheng, MD, PhD (Far Eastern Memorial Hospital, PI of Committee), Jeng-Yuan Hsu, MD, PhD (Taichung Veterans General Hospital, PI of Committee), Wu-Huei Hsu, MD, PhD (China Medical University Hospital, PI of Committee), Ying-Huang Tsai, MD, PhD (Chang Gung Memorial Hospital, Chia-Yi, PI of Committee), Tzuen-Ren Hsiue, MD, PhD (National Cheng Kung University Hospital, PI of Committee), Meng-Chih Lin, MD, PhD (Chang Gung Memorial Hospital, Kaohsiung, PI of Committee), Hen-I Lin, MD (Cardinal Tien Hospital, PI of Committee), Cheng-Yi Wang, MD, PhD (Cardinal Tien Hospital, PI of Committee), Yeun-Chung Chang, MD, PhD (NTUH, PI of Committee), Ueng-Cheng Yang, PhD (National Yang-Ming University, PI of Committee), Chung-Ming Chen, PhD (NTUH, PI of Committee), Cing-Syong Lin, MD, PhD (Changhua Christian Hospital, PI of Committee), Likwang Chen, PhD (National Health Research Institutes, PI of Committee), Yu-Feng Wei, MD (E-Da Hospital, PI of Committee), Inn-Wen Chong, MD (Kaohsiung Medical University Chung-Ho Memorial Hospital, PI of Committee), Chung-Yu Chen(NTUH, Yun-Lin, PI of Committee). This work was supported by Taiwan National Science Foundation grants NSC 101-2325-B-002-064, NSC 102-2325-B-002-087, NSC 103-2325-B-002-027, NSC 104-2325-B-002-035, and NSC-105), Cardinal Tien Hospital (CTH105A-205, CTH106A-2B05, CTH107A-2A13, and CTH108A-2A14) and from National Health Research Institutes (intramural funding). Publisher Copyright: {\textcopyright} Wang et al.",
year = "2019",
month = sep,
day = "1",
doi = "10.18632/aging.102217",
language = "English",
volume = "11",
pages = "6863--6871",
journal = "Aging",
issn = "1945-4589",
publisher = "US Administration on Aging",
number = "17",
}