TY - JOUR
T1 - Risk patterns associated with transient hearing impairment and permanent hearing loss in infants born very preterm
T2 - A retrospective study
AU - Yu, Wen Hao
AU - Lin, Yung Chieh
AU - Chu, Chi Hsiang
AU - Chen, Ray Bing
AU - Wu, Jiunn Liang
AU - Huang, Chao Ching
N1 - Funding Information:
We thank Chien-Jung Ho and Ting-Jyun Jhuo at the Preterm Research Center of National Cheng Kung University, and Yzu-Yu Liu from the Taiwan Premature Baby Foundation, for data collection and follow-up assessment of the children born preterm. This manuscript was edited by Wallace Academic Editing.
Funding Information:
The Taiwan Ministry of Science and Technology (MOST 110‐2314‐B‐006‐057; MOST‐110‐2314‐B‐006‐113) and the National Cheng Kung University Hospital (NCKUH‐ 11101001).
Publisher Copyright:
© 2022 Mac Keith Press.
PY - 2023/4
Y1 - 2023/4
N2 - Aim: To determine the risk patterns associated with transient hearing impairment (THI) and permanent hearing loss (PHL) of infants born very preterm who failed hearing screenings. Method: We enrolled 646 infants (347 males, 299 females) born at no more than 30 weeks' gestation between 2006 and 2020 who received auditory brainstem response screening at term-equivalent age. Audiological examinations of infants who failed the screening revealed THI, when hearing normalized, or PHL, defined as a persistent unilateral or bilateral hearing threshold above 20 dB. Principal component analysis (PCA) was used to characterize risk patterns. Results: Among the 646 infants, 584 (90.4%) had normal hearing, 42 (6.5%) had THI, and 20 (3.1%) had PHL. Compared with the group with normal hearing, the THI and PHL groups had significantly higher rates of neurodevelopmental impairment at 24 months corrected age. PCA of risk patterns showed the THI group and especially the PHL group had more severe haemodynamic and respiratory instability. Moreover, severe intraventricular haemorrhage (IVH) was also a risk for PHL. Propensity score matching revealed an association of haemodynamic and respiratory instability with PHL. Interpretation: In infants born preterm, the severity and duration of haemodynamic and respiratory instability are risk patterns for both THI and PHL; severe IVH is an additional risk for PHL. What this paper adds: Neurodevelopmental delay was more common in infants born preterm who failed hearing screening. Principal component analysis revealed the risk patterns associated with hearing impairment. Haemodynamic–respiratory instability was associated with transient and permanent hearing impairment outcomes. Severe haemodynamic–respiratory instability and intraventricular haemorrhage was associated with permanent hearing loss.
AB - Aim: To determine the risk patterns associated with transient hearing impairment (THI) and permanent hearing loss (PHL) of infants born very preterm who failed hearing screenings. Method: We enrolled 646 infants (347 males, 299 females) born at no more than 30 weeks' gestation between 2006 and 2020 who received auditory brainstem response screening at term-equivalent age. Audiological examinations of infants who failed the screening revealed THI, when hearing normalized, or PHL, defined as a persistent unilateral or bilateral hearing threshold above 20 dB. Principal component analysis (PCA) was used to characterize risk patterns. Results: Among the 646 infants, 584 (90.4%) had normal hearing, 42 (6.5%) had THI, and 20 (3.1%) had PHL. Compared with the group with normal hearing, the THI and PHL groups had significantly higher rates of neurodevelopmental impairment at 24 months corrected age. PCA of risk patterns showed the THI group and especially the PHL group had more severe haemodynamic and respiratory instability. Moreover, severe intraventricular haemorrhage (IVH) was also a risk for PHL. Propensity score matching revealed an association of haemodynamic and respiratory instability with PHL. Interpretation: In infants born preterm, the severity and duration of haemodynamic and respiratory instability are risk patterns for both THI and PHL; severe IVH is an additional risk for PHL. What this paper adds: Neurodevelopmental delay was more common in infants born preterm who failed hearing screening. Principal component analysis revealed the risk patterns associated with hearing impairment. Haemodynamic–respiratory instability was associated with transient and permanent hearing impairment outcomes. Severe haemodynamic–respiratory instability and intraventricular haemorrhage was associated with permanent hearing loss.
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U2 - 10.1111/dmcn.15440
DO - 10.1111/dmcn.15440
M3 - Article
C2 - 36284369
AN - SCOPUS:85140375453
SN - 0012-1622
VL - 65
SP - 479
EP - 488
JO - Developmental Medicine and Child Neurology
JF - Developmental Medicine and Child Neurology
IS - 4
ER -