RNA interference technology used for the study of aquatic virus infections

Mohammad Latif Reshi, Jen Leih Wu, Hao-Ven Wang, Jiann-Ruey Hong

研究成果: Review article同行評審

12 引文 斯高帕斯(Scopus)

摘要

Aquaculture is one of the most important economic activities in Asia and is presently the fastest growing sector of food production in the world. Explosive increases in global fish farming have been accompanied by an increase in viral diseases. Viral infections are responsible for huge economic losses in fish farming, and control of these viral diseases in aquaculture remains a serious challenge. Recent advances in biotechnology have had a significant impact on disease reduction in aquaculture. RNAi is one of the most important technological breakthroughs in modern biology, allowing us to directly observe the effects of the loss of specific genes in living systems. RNA interference technology has emerged as a powerful tool for manipulating gene expression in the laboratory. This technology represents a new therapeutic approach for treating aquatic diseases, including viral infections. RNAi technology is based on a naturally occurring post-transcriptional gene silencing process mediated by the formation of dsRNA. RNAi has been proven widely effective for gene knockdown in mammalian cultured cells, but its utility in fish remains unexplored. This review aims to highlight the RNAi technology that has made significant contributions toward the improvement of aquatic animal health and will also summarize the current status and future strategies concerning the therapeutic applications of RNAi to combat viral disease in aquacultured organisms.

原文English
頁(從 - 到)14-23
頁數10
期刊Fish and Shellfish Immunology
40
發行號1
DOIs
出版狀態Published - 2014 一月 1

All Science Journal Classification (ASJC) codes

  • Environmental Chemistry
  • Aquatic Science

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