Roles of prostaglandin E2 in endometriosis

Kuei Yang Hsiao, Meng Hsing Wu, Shaw Jenq Tsai

研究成果: Chapter

摘要

Endometriosis is one of the most common gynecological diseases, affecting approximately 10 % of women in reproductive age. It is characterized as the presence of endometrial-like glands and stroma outside the uterus, commonly on the pelvic peritoneum and ovaries. The major symptoms of endometriosis include pelvic pain, dysmenorrhea, dyspareunia, and infertility. During the past decade, intensive investigations on molecular mechanisms responsible for the pathological processes of endometriosis have been conducted. Although many factors have been reported to be involved in these processes, prostaglandin E2 (PGE2) no doubt represents as one of the most critical regulators of all. Accumulating data demonstrate that PGE2 controls many critical functions, such as steroidogenesis, angiogenesis, proliferation, and immune suppression that contribute to the pathogenesis of endometriosis. Herein, we will summarize the most up-to-date information regarding the functional roles of PGE2 in the development and maintenance of endometriosis.

原文English
主出版物標題Endometriosis
主出版物子標題Pathogenesis and Treatment
發行者Springer Japan
頁面125-146
頁數22
9784431544210
ISBN(電子)9784431544210
ISBN(列印)4431544208, 9784431544203
DOIs
出版狀態Published - 2014 一月 1

All Science Journal Classification (ASJC) codes

  • 醫藥 (全部)

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