Rosacea with persistent facial erythema and high Demodex density effectively treated with topical ivermectin alone or combined with oral carvedilol

Hui Peng Huang, Chao Kai Hsu, Julia Yu Yun Lee

研究成果: Article同行評審

摘要

Topical ivermectin is effective in treating papulopustular rosacea, but its effect on persistent facial erythema of rosacea with high Demodex densities has not been well documented. We retrospectively reviewed 39 rosacea patients with persistent facial erythema and high Demodex densities. Clinician's erythema assessment (CEA) and Demodex density were evaluated before and after topical ivermectin alone or combined with oral carvedilol. Three patients (all with papulopustular rosacea, in ivermectin group) dropped out due to early ivermectin-induced local flare of rosacea. In the remaining patients (ivermectin group n = 14; ivermectin-carvedilol group n = 22), the CEA grade and Demodex density were significantly reduced, both P <.01. There was no statistically significant difference between the two groups in CEA before and after treatment (P =.07 and P =.23, respectively), and in Demodex density (P =.82 and.10, respectively). Both regimens markedly improved the persistent facial erythema with response being excellent in 26 of 36 patients (72%), good in 2, fair in 4 and none in 4. There was a correlation between the reduction of CEA and Demodex density after treatment (rho = 0.50, P =.002). The results showed that topical ivermectin was effective in reducing persistent facial erythema of rosacea with Demodex overgrowth.

原文English
文章編號e14899
期刊Dermatologic Therapy
34
發行號2
DOIs
出版狀態Published - 2021 三月 1

All Science Journal Classification (ASJC) codes

  • Dermatology

指紋 深入研究「Rosacea with persistent facial erythema and high Demodex density effectively treated with topical ivermectin alone or combined with oral carvedilol」主題。共同形成了獨特的指紋。

引用此