Routine clinical evaluation of cerebrovascular reserve capacity using carbogen in patients with intracranial stenosis

Manus J. Donahue, Lindsey M. Dethrage, Carlos C. Faraco, Lori C. Jordan, Paul Clemmons, Robert Singer, J. Mocco, Yu Shyr, Aditi Desai, Anne O'Duffy, Derek Riebau, Lisa Hermann, John Connors, Howard Kirshner, Megan K. Strother

研究成果: Article

43 引文 斯高帕斯(Scopus)

摘要

BACKGROUND AND PURPOSE - : A promising method for identifying hemodynamic impairment that may serve as a biomarker for stroke risk in patients with intracranial stenosis is cerebrovascular reactivity (CVR) mapping using noninvasive MRI. Here, abilities to measure CVR safely in the clinic using hypercarbic hyperoxic (carbogen) gas challenges, which increase oxygen delivery to tissue, are investigated. METHODS - : In sequence with structural and angiographic imaging, blood oxygenation level-dependent carbogen-induced CVR scans were performed in patients with symptomatic intracranial stenosis (n=92) and control (n=10) volunteers, with a subgroup of patients (n=57) undergoing cerebral blood flow-weighted pseudocontinuous arterial spin labeling CVR. Subjects were stratified for 4 substudies to evaluate relationships between (1) carbogen and hypercarbic normoxic CVR in healthy tissue (n=10), (2) carbogen cerebral blood flow CVR and blood oxygenation level-dependent CVR in intracranial stenosis patients (n=57), (3) carbogen CVR and clinical measures of disease in patients with asymmetrical intracranial atherosclerotic (n=31) and moyamoya (n=29) disease, and (4) the CVR scan and immediate and longer-term complications (n=92). RESULTS - : Noninvasive blood oxygenation level-dependent carbogen-induced CVR values correlate with (1) lobar hypercarbic normoxic gas stimuli in healthy tissue (R=0.92; P<0.001), (2) carbogen-induced cerebral blood flow CVR in patients with intracranial stenosis (R=0.30-0.33; P<0.012), and (3) angiographic measures of disease severity both in atherosclerotic and moyamoya patients after appropriate processing. No immediate stroke-related complications were reported in response to carbogen administration; longer-term neurological events fell within the range for expected events in this patient population. CONCLUSIONS - : Carbogen-induced CVR elicited no added adverse events and provided a surrogate marker of cerebrovascular reserve consistent with intracranial vasculopathy.

原文English
頁(從 - 到)2335-2341
頁數7
期刊Stroke
45
發行號8
DOIs
出版狀態Published - 2014 八月

All Science Journal Classification (ASJC) codes

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialised Nursing

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    Donahue, M. J., Dethrage, L. M., Faraco, C. C., Jordan, L. C., Clemmons, P., Singer, R., Mocco, J., Shyr, Y., Desai, A., O'Duffy, A., Riebau, D., Hermann, L., Connors, J., Kirshner, H., & Strother, M. K. (2014). Routine clinical evaluation of cerebrovascular reserve capacity using carbogen in patients with intracranial stenosis. Stroke, 45(8), 2335-2341. https://doi.org/10.1161/STROKEAHA.114.005975