Sample flow switching techniques on microfluidic chips

Yu Jen Pan, Jin Jie Lin, Win Jet Luo, Ruey Jen Yang

研究成果: Article同行評審

24 引文 斯高帕斯(Scopus)

摘要

This paper presents an experimental investigation into electrokinetically focused flow injection for bio-analytical applications. A novel microfluidic device for microfluidic sample handling is presented. The microfluidic chip is fabricated on glass substrates using conventional photolithographic and chemical etching processes and is bonded using a high-temperature fusion method. The proposed valve-less device is capable not only of directing a single sample flow to a specified output port, but also of driving multiple samples to separate outlet channels or even to a single outlet to facilitate sample mixing. The experimental results confirm that the sample flow can be electrokinetically pre-focused into a narrow stream and guided to the desired outlet port by means of a simple control voltage model. The microchip presented within this paper has considerable potential for use in a variety of applications, including high-throughput chemical analysis, cell fusion, fraction collection, sample mixing, and many other applications within the micro-total-analysis systems field.

原文English
頁(從 - 到)1644-1648
頁數5
期刊Biosensors and Bioelectronics
21
發行號8
DOIs
出版狀態Published - 2006 二月 15

All Science Journal Classification (ASJC) codes

  • 生物技術
  • 生物物理學
  • 生物醫學工程
  • 電化學

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