Schisanhenol ameliorates oxLDL-caused endothelial dysfunction by inhibiting LOX-1 signaling

Tsan Hung Chiu, Chang Wen Ku, Tsung Jung Ho, Kun Ling Tsai, Yi Dung Yang, Hsiu Chung Ou, Hsiu I. Chen

研究成果: Article同行評審

1 引文 斯高帕斯(Scopus)

摘要

Atherosclerotic lesions play a critical role in leading cardiovascular diseases. Oxidized low-density lipoprotein (OxLDL) is a vital risk factor for atherosclerosis since it acts a crucial role in endothelial dysfunction and foam cell formation. Schisanhenol, a composition extracted from the fruit of Schisandra rubriflora, has been reported to have antioxidative effects on human LDL oxidation. This study investigates whether Schisanhenol protects against oxLDL-mediated endothelial damage by modulating the lectin-like oxLDL receptor-1 (LOX-1)-mediated inflammatory processes. Human umbilical vein endothelial cells (HUVECs) were pre-treated with 10 or 20 μM Schisanhenol for 2 h and then exposed to 150 μg/mL oxLDL. We revealed that Schisanhenol reduced oxLDL-enhanced LOX-1 expression. We also found that oxLDL down-regulated endothelial nitric oxide synthase (eNOS) as well as activated inducible NOS (iNOS), thereby enhancing the generation of nitric oxide (NO). Moreover, oxLDL elevated the expression levels of phosphorylated-p38MAPK, subsequently promoting NF-κB-modulated inflammatory responses. Pretreatment with Schisanhenol exerted significant cytoprotective function in all the above-mentioned detrimental events. Results from this present study reveal that Schisanhenol has a potential therapeutic effect on preventing oxLDL-induced endothelial injuries.

原文English
頁(從 - 到)1589-1596
頁數8
期刊Environmental Toxicology
38
發行號7
DOIs
出版狀態Published - 2023 7月

All Science Journal Classification (ASJC) codes

  • 毒理學
  • 管理、監督、政策法律
  • 健康、毒理學和誘變

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