Schwann-Cell Autophagy, Functional Recovery, and Scar Reduction After Peripheral Nerve Repair

Po-Yen Ko, Cheng Chang Yang, Yao-Lung Kuo, Fong-chin Su, Tai I. Hsu, Yuan Kun Tu, I. Ming Jou

研究成果: Article

4 引文 (Scopus)

摘要

The functional outcome after peripheral nerve repair is often unpredictable for many reasons, e.g., the severity of neuronal death and scarring. Axonal degeneration significantly affects outcomes. Post-injury axonal degeneration in peripheral nerves is accompanied by myelin degradation initiated by Schwann cells (SCs), which activate autophagy, a ubiquitous cytoprotective process essential for degrading and recycling cellular constituents. Scar formation occurs concomitantly with nerve insult and axonal degeneration. The association between SC autophagy and the mechanisms of nerve scar formation is still unknown. A rat model of peripheral nerve lesions induced by sciatic nerve transection injuries was used to examine the function of autophagy in fibrosis reduction during the early phase of nerve repair. Rats were treated with rapamycin (autophagy inducer) or 3-methyladenine (autophagy inhibitor). One week after the nerve damage, fibrosis was potently inhibited in rapamycin-treated rats and, based on gait analysis, yielded a better functional outcome. Immunohistochemistry showed that the autophagic activity of SCs and the accumulation of neurofilaments were upregulated in rapamycin-treated rats. A deficiency of SC autophagic activity might be an early event in nerve scar formation, and modulating autophagy might be a powerful pharmacological approach for improving functional outcomes.

原文English
頁(從 - 到)601-610
頁數10
期刊Journal of Molecular Neuroscience
64
發行號4
DOIs
出版狀態Published - 2018 四月 1

指紋

Schwann Cells
Autophagy
Peripheral Nerves
Cicatrix
Sirolimus
Fibrosis
Sciatic Neuropathy
Intermediate Filaments
Wounds and Injuries
Recycling
Myelin Sheath
Gait
Immunohistochemistry
Pharmacology

All Science Journal Classification (ASJC) codes

  • Cellular and Molecular Neuroscience

引用此文

Ko, Po-Yen ; Yang, Cheng Chang ; Kuo, Yao-Lung ; Su, Fong-chin ; Hsu, Tai I. ; Tu, Yuan Kun ; Jou, I. Ming. / Schwann-Cell Autophagy, Functional Recovery, and Scar Reduction After Peripheral Nerve Repair. 於: Journal of Molecular Neuroscience. 2018 ; 卷 64, 編號 4. 頁 601-610.
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Schwann-Cell Autophagy, Functional Recovery, and Scar Reduction After Peripheral Nerve Repair. / Ko, Po-Yen; Yang, Cheng Chang; Kuo, Yao-Lung; Su, Fong-chin; Hsu, Tai I.; Tu, Yuan Kun; Jou, I. Ming.

於: Journal of Molecular Neuroscience, 卷 64, 編號 4, 01.04.2018, p. 601-610.

研究成果: Article

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