Selective N-debenzylation of amides with p-TsOH

Ching Yuh Chern, Yu Ping Huang, Wai Ming Kan

研究成果: Article同行評審

39 引文 斯高帕斯(Scopus)

摘要

N-Benzylamides were debenzylated efficiently with 4 equiv. of p-TsOH in refluxing toluene. Good to quantitative yields of the desired primary amides were obtained within 2-4 h from a wide variety of N-2,4-dimethoxybenzylamides. N-4-Methoxylbenzyl amides and N-benzylamides were also debenzylated cleanly. In the case of N-2,4-dimethoxylbenzylamides, selective N-debenzylation was possible in the presence of N-Fmoc, N-t-BOC or N-trityl-protection. Protected amino acid amides survived these conditions without any detectable epimerization.

原文English
頁(從 - 到)1039-1041
頁數3
期刊Tetrahedron Letters
44
發行號5
DOIs
出版狀態Published - 2003 一月 27

All Science Journal Classification (ASJC) codes

  • 生物化學
  • 藥物發現
  • 有機化學

指紋

深入研究「Selective N-debenzylation of amides with p-TsOH」主題。共同形成了獨特的指紋。

引用此