Sensing of diseased mitochondria proportion by DEP at the organelle level of intact cells

Pei Yin Chi, Ting Wei Chuang, Tzu Tsai Chu, Chia Tzu Kuo, Yu Ting Wu, Vahid Farmehini, Dar Bin Shieh, Fan Gang Tseng, Yau Huei Wei, Nathan Swami, Chia Fu Chou

研究成果: Conference contribution

1 引文 斯高帕斯(Scopus)


To monitor the healthiness of cells, it is very important to develop quick ways to characterize cells with the diseased and normal mitochondria. Thus, we can take measures to prevent potential development of mitochondria-related diseases. Physical study and systemic proof of concept by engineering method to perform quick diagnosis of the normal and diseased mitochondria have not been well achieved yet. In this study, we used insulator dielectrophoresis (i-DEP), by utilizing the intrinsic dielectric response of a cell to an external AC electric field to differentiate cells containing partially diseased and normal mitochondria to test if we can select diseased mitochondria-containing cells but not the normal cells. We found that it is possible to detect the diseased and healthy mitochondria in cells without breaking the cell membrane. Taking advantage of the dielectrophoresis, DEP principle, we may develop a quick diagnostic method to detect diseased mitochondria in living cells.

主出版物標題Microfluidics, BioMEMS, and Medical Microsystems XVIII
編輯Bonnie L. Gray, Holger Becker
出版狀態Published - 2020
事件Microfluidics, BioMEMS, and Medical Microsystems XVIII 2020 - San Francisco, United States
持續時間: 2020 2月 12020 2月 4


名字Progress in Biomedical Optics and Imaging - Proceedings of SPIE


ConferenceMicrofluidics, BioMEMS, and Medical Microsystems XVIII 2020
國家/地區United States
城市San Francisco

All Science Journal Classification (ASJC) codes

  • 電子、光磁材料
  • 原子與分子物理與光學
  • 生物材料
  • 放射學、核子醫學和影像學


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