Separation of mitochondrial diseased cells based on organelle-level difference using a dep microfluidic system

Pei Yin Chi, Ting Wei Chuang, Tzu Tsai Chu, Chia Tzu Kuo, Yu Ting Wu, Vahid Farmehini, Dar Bin Shieh, Fan Gang Tseng, Yau Huei Wei, Nathan Swami, Chia Fu Chou

研究成果: Conference contribution

摘要

It is imperative to develop tools to characterize cells with the diseased and normal mitochondria to monitor the healthiness of cells and take preventive measures for potential mitochondrial disease development. Here, we adopt insulator dielectrophoresis (i-DEP), by utilizing the intrinsic dielectric response of a cell to an external AC electric field to differentiate cells, containing partially diseased and normal mitochondria. Taking advantage of dielectrophoresis, DEP, principle, we developed a quick diagnostic method to detect mitochondrial disease in living cells, which is not readily achievable by conventional cell cytometry.

原文English
主出版物標題23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
發行者Chemical and Biological Microsystems Society
頁面1372-1373
頁數2
ISBN(電子)9781733419000
出版狀態Published - 2019
事件23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019 - Basel, Switzerland
持續時間: 2019 10月 272019 10月 31

出版系列

名字23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019

Conference

Conference23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
國家/地區Switzerland
城市Basel
期間19-10-2719-10-31

All Science Journal Classification (ASJC) codes

  • 生物工程
  • 化學工程(雜項)

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