Separation of phenylacetic acid, 6‐aminopenicillanic acid and penicillin G with electrodialysis under constant current

Dong‐Hwang ‐H Chen, Sung‐Shyong ‐S Wang, Ting‐Chia ‐C Huang

研究成果: Article同行評審

18 引文 斯高帕斯(Scopus)

摘要

The separation behavior of phenylacetic acid (PAA), 6‐aminopenicillanic acid (6‐APA) and penicillin‐G (Pen‐G) with electrodialysis under constant current was studied. The effects of ionic concentrations and current density on their separation behavior were investigated. The sorption of PAA, 6‐APA and Pen‐G and in the anion exchange membrane, and the variations of the applied voltage and current efficiencies with time during electrodialysis were also examined. It was found that the molecular size and the affinity toward the anion exchange membrane played a key role for the electrodialysis of PAA, 6‐APA and Pen‐G. Phenylacetic acid had the lowest affinity toward the membrane but the fastest transport rate. Penicillin‐G had the highest affinity toward the membrane but the slowest transport rate. With the increase of Pen‐G concentration, the concentration polarization of Pen‐G in the vicinity of anion exchange membrane became very serious, which severely retarded the transport of PAA and 6‐APA. Although the increase of current density accelerated the transport of PAA, 6‐APA and Pen‐G, more serious concentration polarization of Pen‐G occurred and the separation ratio of PAA to 6‐APA decreased.

原文English
頁(從 - 到)284-292
頁數9
期刊Journal of Chemical Technology & Biotechnology
64
發行號3
DOIs
出版狀態Published - 1995 11月

All Science Journal Classification (ASJC) codes

  • 生物技術
  • 化學工程 (全部)
  • 可再生能源、永續發展與環境
  • 燃料技術
  • 廢物管理和處置
  • 污染
  • 有機化學
  • 無機化學

指紋

深入研究「Separation of phenylacetic acid, 6‐aminopenicillanic acid and penicillin G with electrodialysis under constant current」主題。共同形成了獨特的指紋。

引用此