SEPT12 deficiency causes sperm nucleus damage and developmental arrest of preimplantation embryos

Ying Hung Lin, Chuan Kai Chou, Yu Ching Hung, I. Shing Yu, Hsien An Pan, Shu Wha Lin, Pao Lin Kuo

研究成果: Article同行評審

25 引文 斯高帕斯(Scopus)

摘要

Oocytes fertilized with spermatozoa obtained from Septin 12+/- chimeric mice failed to develop beyond the morula stage after IVF and intracytoplasmic sperm injection because of significant DNA defects in the spermatozoa. Given that SEPT12 is expressed at the edge of the sperm nucleus in both humans and mice, we hypothesized the vital roles of Septin 12 in sperm head shaping, nuclear DNA condensation, and early embryonic development.

原文English
頁(從 - 到)363-365
頁數3
期刊Fertility and Sterility
95
發行號1
DOIs
出版狀態Published - 2011 一月

All Science Journal Classification (ASJC) codes

  • 生殖醫學
  • 婦產科

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