Serological responses triggered by different SARS-CoV-2 vaccines against SARS-CoV-2 variants in Taiwan

Chiao Hsuan Chao, Dayna Cheng, Sheng Wen Huang, Yung Chun Chuang, Trai Ming Yeh, Jen Ren Wang

研究成果: Article同行評審

4 引文 斯高帕斯(Scopus)

摘要

Broadly neutralizing ability is critical for developing the next-generation SARS-CoV-2 vaccine. We collected sera samples between December 2021-January 2022 from 113 Taiwan naïve participants after their second dose of homologous vaccine (AZD1222, mRNA-1273, BNT162-b2, and MVC-COV1901) and compared the differences in serological responses of various SARS-CoV-2 vaccines. Compared to AZD1222, the two mRNA vaccines could elicit a higher level of anti-S1-RBD binding antibodies with higher broadly neutralizing ability evaluated using pseudoviruses of various SARS-CoV-2 lineages. The antigenic maps produced from the neutralization data implied that Omicron represents very different antigenic characteristics from the ancestral lineage. These results suggested that constantly administering the vaccine with ancestral Wuhan spike is insufficient for the Omicron outbreak. In addition, we found that anti-ACE2 autoantibodies were significantly increased in all four vaccinated groups compared to the unvaccinated pre-pandemic group, which needed to be investigated in the future.

原文English
文章編號1023943
期刊Frontiers in Immunology
13
DOIs
出版狀態Published - 2022 11月 15

All Science Journal Classification (ASJC) codes

  • 免疫學和過敏
  • 免疫學

指紋

深入研究「Serological responses triggered by different SARS-CoV-2 vaccines against SARS-CoV-2 variants in Taiwan」主題。共同形成了獨特的指紋。

引用此