Serum lipids and lipoprotein(a) concentrations in Chinese NIDDM patients: Relation to metabolic control

Chih Jen Chang, Jau Tsuen Kao, Ta Jen Wu, Feng Hwa Lu, Tong Yuan Tai

研究成果: Article同行評審

32 引文 斯高帕斯(Scopus)

摘要

OBJECTIVE- To compare serum blood lipids and lipoprotein(a) [Lp(a)] levels in Chinese non-insulin-dependent diabetes mellitus (NIDDM) patients and nondiabetic control subjects and also to determine the influence of diabetes control on serum Lp(a) concentration in Chinese individuals. RESEARCH DESIGN AND METHODS- We compared the serum blood lipids and Lp(a) levels in NIDDM patients (n = 100) and age- and sex-matched nondiabetic subjects (n = 100) who participated in a case-control study. Comparisons of Lp(a) concentrations were made between a normal control group, a group of diabetic patients with HbA(1c) <8.0%, and a group of diabetic patients with HbA(1c) of 8% or higher. RESULTS- The diabetic patients had higher total triglyceride, apolipoprotein B (apo B), and apo B-to-apo AI ratios, but lower high-density lipoprotein (HDL) cholesterol and apo AI concentrations than nondiabetic controls (P < 0.001, P < 0.01, P < 0.001, P < 0.05, and P < 0.001, respectively). A similar pattern of distribution of Lp(a) levels according to the degree of metabolic control was seen in patients with NIDDM and nondiabetic controls. No correlation was observed between Lp(a) levels and total cholesterol, low- density lipoprotein cholesterol, HDL cholesterol, apo AI, apo B, and triglyceride levels in all diabetic patients. No difference in the Lp(a) levels was noted between diabetic patients and nondiabetic subjects, even in poorly controlled diabetic patients. CONCLUSIONS- In conclusion, Lp(a) levels are not elevated in diabetic patients, even in poorly controlled metabolic conditions.

原文English
頁(從 - 到)1191-1194
頁數4
期刊Diabetes Care
18
發行號8
DOIs
出版狀態Published - 1995 8月

All Science Journal Classification (ASJC) codes

  • 內科學
  • 內分泌學、糖尿病和代謝
  • 高級和專業護理

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