Sesamol attenuates oxidative stress-mediated experimental acute pancreatitis in rats

P. Y. Chu, P. Srinivasan, J. F. Deng, M. Y. Liu

研究成果: Article同行評審

15 引文 斯高帕斯(Scopus)


Acute pancreatitis is a potentially fatal disease with no known cure. The initial events in acute pancreatitis may occur within the acinar cells. We examined the effect of sesamol on (i) a cerulein-induced pancreatic acinar cancer cell line, AR42J, and (ii) cerulein-induced experimental acute pancreatitis in rats. Sesamol inhibited amylase activity and increased cell survival. It also inhibited medium lipid peroxidation and 8- hydroxydeoxyguanosine in AR42J cells compared with the cerulein-alone groups. In addition, in cerulein-treated rats, sesamol inhibited serum amylase and lipase levels, pancreatic edema, and lipid peroxidation, but it increased pancreatic glutathione and nitric oxide levels. Thus, we hypothesize that sesamol attenuates cerulein-induced experimental acute pancreatitis by inhibiting the pancreatic acinar cell death associated with oxidative stress in rats.

頁(從 - 到)397-404
期刊Human and Experimental Toxicology
出版狀態Published - 2012 4月

All Science Journal Classification (ASJC) codes

  • 毒理學
  • 健康、毒理學和誘變


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