TY - JOUR
T1 - Sesamol attenuates oxidative stress-mediated experimental acute pancreatitis in rats
AU - Chu, P. Y.
AU - Srinivasan, P.
AU - Deng, J. F.
AU - Liu, M. Y.
N1 - Funding Information:
This study was supported by grant NSC-96-2628-B-006-038-MY3 from the National Science Council, Taiwan.
PY - 2012/4
Y1 - 2012/4
N2 - Acute pancreatitis is a potentially fatal disease with no known cure. The initial events in acute pancreatitis may occur within the acinar cells. We examined the effect of sesamol on (i) a cerulein-induced pancreatic acinar cancer cell line, AR42J, and (ii) cerulein-induced experimental acute pancreatitis in rats. Sesamol inhibited amylase activity and increased cell survival. It also inhibited medium lipid peroxidation and 8- hydroxydeoxyguanosine in AR42J cells compared with the cerulein-alone groups. In addition, in cerulein-treated rats, sesamol inhibited serum amylase and lipase levels, pancreatic edema, and lipid peroxidation, but it increased pancreatic glutathione and nitric oxide levels. Thus, we hypothesize that sesamol attenuates cerulein-induced experimental acute pancreatitis by inhibiting the pancreatic acinar cell death associated with oxidative stress in rats.
AB - Acute pancreatitis is a potentially fatal disease with no known cure. The initial events in acute pancreatitis may occur within the acinar cells. We examined the effect of sesamol on (i) a cerulein-induced pancreatic acinar cancer cell line, AR42J, and (ii) cerulein-induced experimental acute pancreatitis in rats. Sesamol inhibited amylase activity and increased cell survival. It also inhibited medium lipid peroxidation and 8- hydroxydeoxyguanosine in AR42J cells compared with the cerulein-alone groups. In addition, in cerulein-treated rats, sesamol inhibited serum amylase and lipase levels, pancreatic edema, and lipid peroxidation, but it increased pancreatic glutathione and nitric oxide levels. Thus, we hypothesize that sesamol attenuates cerulein-induced experimental acute pancreatitis by inhibiting the pancreatic acinar cell death associated with oxidative stress in rats.
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U2 - 10.1177/0960327111426583
DO - 10.1177/0960327111426583
M3 - Article
C2 - 22076497
AN - SCOPUS:84860466197
SN - 0960-3271
VL - 31
SP - 397
EP - 404
JO - Human and Experimental Toxicology
JF - Human and Experimental Toxicology
IS - 4
ER -
