Sharp, an inducible cofactor that integrates nuclear receptor repression and activation

Yanhong Shi, Michael Downes, Wen Xie, Hung Ying Kao, Peter Ordentlich, Chih Cheng Tsai, Michelle Hon, Ronald M. Evans

研究成果: Article

247 引文 斯高帕斯(Scopus)

摘要

A yeast two-hybrid screen using the conserved carboxyl terminus of the nuclear receptor corepressor SMRT as a bait led to the isolation of a novel human gene termed SHARP (SMRT/HDAC1 Associated Repressor Protein). SHARP is a potent transcriptional repressor whose repression domain (RD) interacts directly with SMRT and at least five members of the NuRD complex including HDAC1 and HDAC2. In addition, SHARP binds to the steroid receptor RNA coactivator SRA via an intrinsic RNA binding domain and suppresses SRA-potentiated steroid receptor transcription activity. Accordingly, SHARP has the capacity to modulate both liganded and nonliganded nuclear receptors. Surprisingly, the expression of SHARP is itself steroid inducible, suggesting a simple feedback mechanism for attenuation of the hormonal response.

原文English
頁(從 - 到)1140-1151
頁數12
期刊Genes and Development
15
發行號9
DOIs
出版狀態Published - 2001 五月 1

All Science Journal Classification (ASJC) codes

  • Genetics
  • Developmental Biology

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    Shi, Y., Downes, M., Xie, W., Kao, H. Y., Ordentlich, P., Tsai, C. C., Hon, M., & Evans, R. M. (2001). Sharp, an inducible cofactor that integrates nuclear receptor repression and activation. Genes and Development, 15(9), 1140-1151. https://doi.org/10.1101/gad.871201