Significance of urinary tissue polypeptide specific antigen (TPS). Determination in patients with urothelial carcinoma

Wei-Jen Yao, Chih-Jen Chang, Shih-Huang Chan, Nan-Haw Chow, Hong-Lin Cheng, T. S. Tzai, S. N. Lin

研究成果: Article

15 引文 (Scopus)

摘要

Tissue polypeptide specific antigen (TPS) is the M3 epitope of the tissue polypeptide antigen, and a specific epithelial proliferation marker. To examine the benefit of urine TPS (U-TPS) measurement in the diagnosis and classification of biological properties of transitional cell carcinoma (TCC), a radioimmunoassay of U-TPS was measured in patients with active TCC (n = 56), at tumor-free status (n = 36), with inflammatory urological disease (n = 44), and age-sex adjusted normal subjects (n = 75). Both neoplastic and inflammatory urological diseases had an increase in U-TPS levels (U/ gm creatinine) compared to normal individuals (p = 0.0005), while it normalized in tumor-free condition (p = 0.007). For patients with active TCC, a strong positive association was observed between U-TPS values and both histological grading (p = 0.05) and positive cytology (p = 0.05). U-TPS levels were significantly higher in the presence of nodal or systemic metastasis (p = 0.008 by ANOVA test). Measurement of U-TPS appeared to be an indicator of poor outcome for patients with bladder cancer (p = 0.05 by t test) for a mean follow-up of 26 months. The results indicate that determination of U-TPS can be a supplement in assessing the biological properties of TCC, and may be helpful in identifying patients who need meticulous peri-operative staging survey.

原文English
頁(從 - 到)2819-2823
頁數5
期刊Anticancer research
15
發行號6 B
出版狀態Published - 1995 十二月 1

指紋

Urine
Carcinoma
Transitional Cell Carcinoma
Urologic Diseases
tissue polypeptide specific antigen
Urinary Bladder Neoplasms
Radioimmunoassay
Cell Biology
Epitopes
Creatinine
Neoplasms
Analysis of Variance
Neoplasm Metastasis

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

引用此文

@article{3d13c068104042a3b84e2f37215ab2a5,
title = "Significance of urinary tissue polypeptide specific antigen (TPS). Determination in patients with urothelial carcinoma",
abstract = "Tissue polypeptide specific antigen (TPS) is the M3 epitope of the tissue polypeptide antigen, and a specific epithelial proliferation marker. To examine the benefit of urine TPS (U-TPS) measurement in the diagnosis and classification of biological properties of transitional cell carcinoma (TCC), a radioimmunoassay of U-TPS was measured in patients with active TCC (n = 56), at tumor-free status (n = 36), with inflammatory urological disease (n = 44), and age-sex adjusted normal subjects (n = 75). Both neoplastic and inflammatory urological diseases had an increase in U-TPS levels (U/ gm creatinine) compared to normal individuals (p = 0.0005), while it normalized in tumor-free condition (p = 0.007). For patients with active TCC, a strong positive association was observed between U-TPS values and both histological grading (p = 0.05) and positive cytology (p = 0.05). U-TPS levels were significantly higher in the presence of nodal or systemic metastasis (p = 0.008 by ANOVA test). Measurement of U-TPS appeared to be an indicator of poor outcome for patients with bladder cancer (p = 0.05 by t test) for a mean follow-up of 26 months. The results indicate that determination of U-TPS can be a supplement in assessing the biological properties of TCC, and may be helpful in identifying patients who need meticulous peri-operative staging survey.",
author = "Wei-Jen Yao and Chih-Jen Chang and Shih-Huang Chan and Nan-Haw Chow and Hong-Lin Cheng and Tzai, {T. S.} and Lin, {S. N.}",
year = "1995",
month = "12",
day = "1",
language = "English",
volume = "15",
pages = "2819--2823",
journal = "Anticancer Research",
issn = "0250-7005",
publisher = "International Institute of Anticancer Research",
number = "6 B",

}

TY - JOUR

T1 - Significance of urinary tissue polypeptide specific antigen (TPS). Determination in patients with urothelial carcinoma

AU - Yao, Wei-Jen

AU - Chang, Chih-Jen

AU - Chan, Shih-Huang

AU - Chow, Nan-Haw

AU - Cheng, Hong-Lin

AU - Tzai, T. S.

AU - Lin, S. N.

PY - 1995/12/1

Y1 - 1995/12/1

N2 - Tissue polypeptide specific antigen (TPS) is the M3 epitope of the tissue polypeptide antigen, and a specific epithelial proliferation marker. To examine the benefit of urine TPS (U-TPS) measurement in the diagnosis and classification of biological properties of transitional cell carcinoma (TCC), a radioimmunoassay of U-TPS was measured in patients with active TCC (n = 56), at tumor-free status (n = 36), with inflammatory urological disease (n = 44), and age-sex adjusted normal subjects (n = 75). Both neoplastic and inflammatory urological diseases had an increase in U-TPS levels (U/ gm creatinine) compared to normal individuals (p = 0.0005), while it normalized in tumor-free condition (p = 0.007). For patients with active TCC, a strong positive association was observed between U-TPS values and both histological grading (p = 0.05) and positive cytology (p = 0.05). U-TPS levels were significantly higher in the presence of nodal or systemic metastasis (p = 0.008 by ANOVA test). Measurement of U-TPS appeared to be an indicator of poor outcome for patients with bladder cancer (p = 0.05 by t test) for a mean follow-up of 26 months. The results indicate that determination of U-TPS can be a supplement in assessing the biological properties of TCC, and may be helpful in identifying patients who need meticulous peri-operative staging survey.

AB - Tissue polypeptide specific antigen (TPS) is the M3 epitope of the tissue polypeptide antigen, and a specific epithelial proliferation marker. To examine the benefit of urine TPS (U-TPS) measurement in the diagnosis and classification of biological properties of transitional cell carcinoma (TCC), a radioimmunoassay of U-TPS was measured in patients with active TCC (n = 56), at tumor-free status (n = 36), with inflammatory urological disease (n = 44), and age-sex adjusted normal subjects (n = 75). Both neoplastic and inflammatory urological diseases had an increase in U-TPS levels (U/ gm creatinine) compared to normal individuals (p = 0.0005), while it normalized in tumor-free condition (p = 0.007). For patients with active TCC, a strong positive association was observed between U-TPS values and both histological grading (p = 0.05) and positive cytology (p = 0.05). U-TPS levels were significantly higher in the presence of nodal or systemic metastasis (p = 0.008 by ANOVA test). Measurement of U-TPS appeared to be an indicator of poor outcome for patients with bladder cancer (p = 0.05 by t test) for a mean follow-up of 26 months. The results indicate that determination of U-TPS can be a supplement in assessing the biological properties of TCC, and may be helpful in identifying patients who need meticulous peri-operative staging survey.

UR - http://www.scopus.com/inward/record.url?scp=0029549359&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029549359&partnerID=8YFLogxK

M3 - Article

C2 - 8669871

AN - SCOPUS:0029549359

VL - 15

SP - 2819

EP - 2823

JO - Anticancer Research

JF - Anticancer Research

SN - 0250-7005

IS - 6 B

ER -