This research aims at constructing a simulation-based travel time prediction model for traffic corridors. The simulation-assignment model, DynaTAIWAN is utilized to predict the travel time based on two approaches, a flow-based model and a vehicle-based model. Dynamic origin-destination (O-D) estimation and prediction procedure is developed to prepare O-D demand data, and the estimated O-D flows is used within DynaTAIWAN to simulate vehicle movements. The developed framework is illustrated for a traffic corridor and validated through empirical data. Empirical data for signalized urban network, the travel time from electronic toll stations are used to validate the model.