Simvastatin treatment exerts antidepressant-like effect in rats exposed to chronic mild stress

Pao Yen Lin, Alice Y.W. Chang, Tsu Kung Lin

研究成果: Article同行評審

34 引文 斯高帕斯(Scopus)


Hyperlipidemia is associated with increased risk of coronary artery disease and stroke, both of which, in turn, are risk factors of old-age depression. Statins are extensively used for decreasing cholesterol levels. Clinical investigations revealed that long-term use of statins appeared to be associated with a lower risk of anxiety and depression. However, the antidepressant property of statins has not been well examined. This study aimed at examining the antidepressant-like effects of statins in rats exposed to chronic mild stress (CMS). We found that animals exposed to CMS for 4 weeks developed depressive-like state, shown by forced swim test and sucrose preference test. However, these CMS-induced behavioral changes were reversed by simvastatin (5 or 10 mg/kg/day) for 14 days, comparable to imipramine (10 mg/kg/day) treatment. Locomotor activity and anxiety-like behaviors were not altered by CMS or these treatments. These results demonstrated antidepressant-like effects of statin in CMS model of rats and suggested the potential that statins could be used to facilitate antidepressant treatment in clinical setting.

頁(從 - 到)174-179
期刊Pharmacology Biochemistry and Behavior
出版狀態Published - 2014 9月

All Science Journal Classification (ASJC) codes

  • 生物化學
  • 毒理學
  • 藥理
  • 臨床生物化學
  • 生物精神病學
  • 行為神經科學


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