Single-cell transcriptomics in human skin research: available technologies, technical considerations and disease applications

Georgios Theocharidis, Stavroula Tekkela, Aristidis Veves, John A. McGrath, Alexandros Onoufriadis

研究成果: Review article同行評審

23 引文 斯高帕斯(Scopus)

摘要

Single-cell technologies have revolutionized research in the last decade, including for skin biology. Single-cell RNA sequencing has emerged as a powerful tool allowing the dissection of human disease pathophysiology at unprecedented resolution by assessing cell-to-cell variation, facilitating identification of rare cell populations and elucidating cellular heterogeneity. In dermatology, this technology has been widely applied to inflammatory skin disorders, fibrotic skin diseases, wound healing complications and cutaneous neoplasms. Here, we discuss the available technologies and technical considerations of single-cell RNA sequencing and describe its applications to a broad spectrum of dermatological diseases.

原文English
頁(從 - 到)655-673
頁數19
期刊Experimental Dermatology
31
發行號5
DOIs
出版狀態Published - 2022 5月

All Science Journal Classification (ASJC) codes

  • 生物化學
  • 分子生物學
  • 皮膚科

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