Single-Photon-Emission Computed Tomography Studies with Dopamine and Serotonin Transporters in Opioid Users

研究成果: Chapter

摘要

Opioid dependence is harmful to individuals and society as a whole. Dopamine has been proposed to be involved in the mechanism associated with opioid dependence. Meanwhile, another monoamine neurotransmitter, serotonin, might also play a role. In this chapter, we review the findings from neuroimaging studies that used single-photon-emission computed tomography. In agreement with the dopamine hypothesis of addiction, the findings indicated a 10-30% reduction in dopamine transporter availability among those with opioid dependence. The evidence also implied a certain level of recovery after treatment. A similar effect was also found for serotonin; however, evidence is very scarce. The association between serotonergic activity and treatment outcome is controversial. We discuss the theoretical and clinical implications at the end of this chapter.

原文English
主出版物標題Foundations of Understanding, Tobacco, Alcohol, Cannabinoids and Opioids
發行者Elsevier Inc.
頁面966-973
頁數8
1
ISBN(電子)9780128003763
ISBN(列印)9780128002131
DOIs
出版狀態Published - 2016 三月 23

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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    Lin, S. H., Chen, K-C., & Yang, Y-K. (2016). Single-Photon-Emission Computed Tomography Studies with Dopamine and Serotonin Transporters in Opioid Users. 於 Foundations of Understanding, Tobacco, Alcohol, Cannabinoids and Opioids (卷 1, 頁 966-973). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-800213-1.00090-0