Single pulsed electromagnetic field restores bone mass and microarchitecture in denervation/disuse osteopenic mice

Chih Chun Lin, Yu Ting Chang, Ru Wei Lin, Chih Wei Chang, Gwo Jaw Wang, Kuo An Lai

研究成果: Article同行評審

1 引文 斯高帕斯(Scopus)

摘要

Pulsed electromagnetic fields (PEMFs) have been proposed to treat bone loss. However, time-consuming is the main complaint. A time-saving and effective treatment is of expectation. Previously, we showed a 3 min daily of single pulsed electromagnetic field (SPEMF) accelerated bone formation of long bone defect in mice. Here we compared the effect of SPEMF with PEMF for treating denervation/disuse osteopenic mice. Healthy mice were divided into 3 groups: intact mice (INT), INT + PEMF, and INT + SPEMF. Induced osteopenic mice were divided to osteopenia (IOP), IOP + PEMF, and IOP + SPEMF groups. The PEMF treated groups were subjected to daily 8 h PEMF(15 Hz, 18 G) exposure, while SPEMF treated groups were daily 3 min SPEMF(0.2 Hz, 1 T) exposure. BMD was evaluated every two weeks during the 12 weeks of treatment. Microarchitecture was evaluated on week 12. SPEMF significantly reversed bone loss in IOP mice as early as 6 weeks post-treatment, while PEMF reversed bone loss after 8 weeks. Bone volume was significantly increased in the IOP + PEMF and IOP + SPEMF group. Besides, bone volume and trabecular number of IOP + SPEMF mice were restored to the levels of INT mice in 12 weeks. Our finding suggests SPEMF increased BMD and restored microarchitecture of disuse osteopenic mice to healthy level.

原文English
頁(從 - 到)52-59
頁數8
期刊Medical Engineering and Physics
80
DOIs
出版狀態Published - 2020 六月

All Science Journal Classification (ASJC) codes

  • 生物物理學
  • 生物醫學工程

指紋

深入研究「Single pulsed electromagnetic field restores bone mass and microarchitecture in denervation/disuse osteopenic mice」主題。共同形成了獨特的指紋。

引用此