Social cognitive deficit is associated with visuomotor coordination impairment and dopamine transporter availability in euthymic bipolar disorder

Ying Tsung Tsai, Chih Yu Chang, Cheng Ying Wu, Yu Lien Huang, Hui Hua Chang, Tsung-Hua Lu, Wei Hung Chang, Nan Tsing Chiu, Chia Fen Hsu, Yen-Kuang Yang, Po See Chen, Huai-Hsuan Tseng

研究成果: Article同行評審

1 引文 斯高帕斯(Scopus)

摘要

Background: Extensive evidence has suggested functional connections between co-occurring visuomotor and social cognitive deficits in neuropsychiatric disorders; however, such association has not been studied in bipolar disorder (BD). We aimed to investigate the relationship between visuomotor coordination and social cognition in the euthymic stage of BD (euBD). Given the shared neurobiological underpinnings involving the dopaminergic system and corticostriatal circuitry, we hypothesized a positive correlation between social cognition and visuomotor coordination in euBD patients. Methods: 40 euBD patients and 59 healthy control (HC) participants underwent evaluation of social (Diagnostic Analysis of Nonverbal Accuracy 2-Taiwan version (DANVA-2-TW)), non-social cognitive function and visuomotor coordination. A subgroup of participants completed single-photon emission computed tomography for striatal dopamine transporter (DAT) availability assessment. Results: EuBD patients showed impaired nonverbal emotion recognition (ps ≤ 0.033) and poorer visuomotor coordination (ps < 0.003) compared to HC, with a positive correlation between these two abilities (r = 0.55, p < 0.01). However, after considering potential confounding factors, instead of visuomotor coordination, striatal DAT availability was a unique predictor of emotion recognition accuracy in euBD (beta = 0.33, p = 0.001). Conclusion: Our study result supported a functional association between social cognition and visuomotor coordination in euBD, with striatal dopaminergic dysfunction emerged as a crucial contributing factor in their interrelation.

原文English
頁(從 - 到)158-164
頁數7
期刊Journal of Psychiatric Research
165
DOIs
出版狀態Published - 2023 9月

All Science Journal Classification (ASJC) codes

  • 精神病學和心理健康
  • 生物精神病學

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