Sodium Thiosulfate Improves Hypertension in Rats with Adenine-Induced Chronic Kidney Disease

Chien Ning Hsu, Chih Yao Hou, Guo Ping Chang-Chien, Sufan Lin, Hung Wei Yang, You Lin Tain

研究成果: Article同行評審

6 引文 斯高帕斯(Scopus)


Hypertension is highly prevalent in chronic kidney disease (CKD). Hydrogen sulfide (H2 S) is an endogenously produced gasotransmitter with vasodilator properties. We, hence, investigated whether oral administration of sodium thiosulfate (STS), a clinically applicable H2 S-based therapy, can exert a protective effect against hypertension in an adenine-induced CKD rat model. Eight-week-old male Sprague–Dawley rats were fed with 0.5% adenine chow for 3 weeks to induce CKD. After 1 week, the rats were divided into two groups: one without and one with STS (2 g/kg body weight/day) in drinking water for 2 weeks. Treatment with STS lowered systolic and diastolic blood pressure by 7 and 9 mm Hg, respectively. Renal H2 S-generating enzyme expression was inhibited by CKD, while STS therapy increased plasma levels of H2 S and thiosulfate. Additionally, restoration of nitric oxide bioavailability and rebalance of the renin–angiotensin system may contribute to the protective effects of STS. Our data suggest that the oral administration of STS improves hypertension in an adenine-induced CKD model, which brings us closer to the clinical translation of H2 S-targeting therapy in CKD-induced hypertension.

出版狀態Published - 2022 1月

All Science Journal Classification (ASJC) codes

  • 生物化學
  • 生理學
  • 分子生物學
  • 臨床生物化學
  • 細胞生物學


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