Software-programmable continuous-flow multi-purpose lab-on-a-chip

Ahmed M. Amin, Raviraj Thakur, Seth Madren, Han-Sheng Chuang, Mithuna Thottethodi, T. N. Vijaykumar, Steven T. Wereley, Stephen C. Jacobson

研究成果: Article

14 引文 (Scopus)

摘要

Current lab-on-a-chip (LoC) devices are assay-specific and are custom-built for each single experiment. Performing an experiment requires scientists or engineers to go through the time-consuming process of designing, fabricating, and testing a chip before conducting the actual experiment. This prolonged cycle can take months to complete, increasing effort and cost and reducing productivity. Similarly, minor modifications to an assay protocol re-incur the overheads of the design cycle. In this paper, we develop a multi-purpose, software-programmable Lab-on-a-Chip (SPLoC), where the user simply writes or downloads a program for each experiment. We describe the components necessary to realize the SPLoC, which include a high-level programming language, an abstract instruction set, a runtime and control system, and a microfluidic device. We describe two key features of our high-level language compiler, and describe a novel variable-volume variable-ratio mixer. Finally, we demonstrate our SPLoC on four diverse, real-world assays.

原文English
頁(從 - 到)647-659
頁數13
期刊Microfluidics and Nanofluidics
15
發行號5
DOIs
出版狀態Published - 2013 十一月 1

指紋

Lab-on-a-chip
high level languages
chips
computer programs
Assays
Experiments
lab-on-a-chip devices
compilers
programming languages
cycles
High level languages
microfluidic devices
productivity
Microfluidics
Computer programming languages
engineers
Productivity
costs
Control systems
Network protocols

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Materials Chemistry

引用此文

Amin, A. M., Thakur, R., Madren, S., Chuang, H-S., Thottethodi, M., Vijaykumar, T. N., ... Jacobson, S. C. (2013). Software-programmable continuous-flow multi-purpose lab-on-a-chip. Microfluidics and Nanofluidics, 15(5), 647-659. https://doi.org/10.1007/s10404-013-1180-2
Amin, Ahmed M. ; Thakur, Raviraj ; Madren, Seth ; Chuang, Han-Sheng ; Thottethodi, Mithuna ; Vijaykumar, T. N. ; Wereley, Steven T. ; Jacobson, Stephen C. / Software-programmable continuous-flow multi-purpose lab-on-a-chip. 於: Microfluidics and Nanofluidics. 2013 ; 卷 15, 編號 5. 頁 647-659.
@article{840fb0ad2d114dc194ba1f02f3e6241e,
title = "Software-programmable continuous-flow multi-purpose lab-on-a-chip",
abstract = "Current lab-on-a-chip (LoC) devices are assay-specific and are custom-built for each single experiment. Performing an experiment requires scientists or engineers to go through the time-consuming process of designing, fabricating, and testing a chip before conducting the actual experiment. This prolonged cycle can take months to complete, increasing effort and cost and reducing productivity. Similarly, minor modifications to an assay protocol re-incur the overheads of the design cycle. In this paper, we develop a multi-purpose, software-programmable Lab-on-a-Chip (SPLoC), where the user simply writes or downloads a program for each experiment. We describe the components necessary to realize the SPLoC, which include a high-level programming language, an abstract instruction set, a runtime and control system, and a microfluidic device. We describe two key features of our high-level language compiler, and describe a novel variable-volume variable-ratio mixer. Finally, we demonstrate our SPLoC on four diverse, real-world assays.",
author = "Amin, {Ahmed M.} and Raviraj Thakur and Seth Madren and Han-Sheng Chuang and Mithuna Thottethodi and Vijaykumar, {T. N.} and Wereley, {Steven T.} and Jacobson, {Stephen C.}",
year = "2013",
month = "11",
day = "1",
doi = "10.1007/s10404-013-1180-2",
language = "English",
volume = "15",
pages = "647--659",
journal = "Microfluidics and Nanofluidics",
issn = "1613-4982",
publisher = "Springer Verlag",
number = "5",

}

Amin, AM, Thakur, R, Madren, S, Chuang, H-S, Thottethodi, M, Vijaykumar, TN, Wereley, ST & Jacobson, SC 2013, 'Software-programmable continuous-flow multi-purpose lab-on-a-chip', Microfluidics and Nanofluidics, 卷 15, 編號 5, 頁 647-659. https://doi.org/10.1007/s10404-013-1180-2

Software-programmable continuous-flow multi-purpose lab-on-a-chip. / Amin, Ahmed M.; Thakur, Raviraj; Madren, Seth; Chuang, Han-Sheng; Thottethodi, Mithuna; Vijaykumar, T. N.; Wereley, Steven T.; Jacobson, Stephen C.

於: Microfluidics and Nanofluidics, 卷 15, 編號 5, 01.11.2013, p. 647-659.

研究成果: Article

TY - JOUR

T1 - Software-programmable continuous-flow multi-purpose lab-on-a-chip

AU - Amin, Ahmed M.

AU - Thakur, Raviraj

AU - Madren, Seth

AU - Chuang, Han-Sheng

AU - Thottethodi, Mithuna

AU - Vijaykumar, T. N.

AU - Wereley, Steven T.

AU - Jacobson, Stephen C.

PY - 2013/11/1

Y1 - 2013/11/1

N2 - Current lab-on-a-chip (LoC) devices are assay-specific and are custom-built for each single experiment. Performing an experiment requires scientists or engineers to go through the time-consuming process of designing, fabricating, and testing a chip before conducting the actual experiment. This prolonged cycle can take months to complete, increasing effort and cost and reducing productivity. Similarly, minor modifications to an assay protocol re-incur the overheads of the design cycle. In this paper, we develop a multi-purpose, software-programmable Lab-on-a-Chip (SPLoC), where the user simply writes or downloads a program for each experiment. We describe the components necessary to realize the SPLoC, which include a high-level programming language, an abstract instruction set, a runtime and control system, and a microfluidic device. We describe two key features of our high-level language compiler, and describe a novel variable-volume variable-ratio mixer. Finally, we demonstrate our SPLoC on four diverse, real-world assays.

AB - Current lab-on-a-chip (LoC) devices are assay-specific and are custom-built for each single experiment. Performing an experiment requires scientists or engineers to go through the time-consuming process of designing, fabricating, and testing a chip before conducting the actual experiment. This prolonged cycle can take months to complete, increasing effort and cost and reducing productivity. Similarly, minor modifications to an assay protocol re-incur the overheads of the design cycle. In this paper, we develop a multi-purpose, software-programmable Lab-on-a-Chip (SPLoC), where the user simply writes or downloads a program for each experiment. We describe the components necessary to realize the SPLoC, which include a high-level programming language, an abstract instruction set, a runtime and control system, and a microfluidic device. We describe two key features of our high-level language compiler, and describe a novel variable-volume variable-ratio mixer. Finally, we demonstrate our SPLoC on four diverse, real-world assays.

UR - http://www.scopus.com/inward/record.url?scp=84888134192&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84888134192&partnerID=8YFLogxK

U2 - 10.1007/s10404-013-1180-2

DO - 10.1007/s10404-013-1180-2

M3 - Article

AN - SCOPUS:84888134192

VL - 15

SP - 647

EP - 659

JO - Microfluidics and Nanofluidics

JF - Microfluidics and Nanofluidics

SN - 1613-4982

IS - 5

ER -