Spinal giant cell-rich osteosarcoma-diagnostic dilemma and treatment strategy: A case report

Chen Sheng Tseng, Chia En Wong, Chi Chen Huang, Hao Hsiang Hsu, Jung Shun Lee, Po Hsuan Lee

研究成果: Article同行評審

2 引文 斯高帕斯(Scopus)


BACKGROUND Giant cell-rich osteosarcoma (GCRO) is a rare histological variant of osteosarcoma. Spinal GCROs are extremely rare, with challenging diagnosis and management. Herein, we present a case of spinal GCRO at T2, which was not diagnosed in initial biopsy but after T2 corpectomy. We detailed the clinical course, management strategy, and outcome after a 4-year follow-up. CASE SUMMARY A 17-year-old female patient presented with back pain followed by ascending paresthesia. Spinal computed tomography (CT) and magnetic resonance imaging (MRI) revealed a collapsed T2 vertebra with an enhancing osteolytic mass. CTguided biopsy showed inconclusive morphology. Pathology from T2 corpectomy revealed GCRO. The patient subsequently received neoadjuvant chemotherapy followed by salvage operation of T2 costotransversectomy with grossly-total resection adjuvant chemoradiation. Upon treatment completion, she had complete GCRO remission. The 4-year follow-up spinal MRI showed no tumor recurrence. CONCLUSION Spinal GCRO poses unique challenges in obtaining sufficient tissue diagnosis and complete surgical removal.

頁(從 - 到)7565-7570
期刊World Journal of Clinical Cases
出版狀態Published - 2022 7月 26

All Science Journal Classification (ASJC) codes

  • 一般醫學


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