Stabilizer-free poly(lactide-co-glycolide) nanoparticles for multimodal biomedical probes

Fong Yu Cheng, Saprina Ping Hsien Wang, Chio Hao Su, Tsung Liu Tsai, Ping Ching Wu, Dar Bin Shieh, Jyh Horng Chen, Patrick Ching Ho Hsieh, Chen Sheng Yeh

研究成果: Article

106 引文 (Scopus)

摘要

Apart from the reported PLGA submicro- and microspheres with broad size distribution, we have successfully developed a methodology using nanoprecipitation to prepare different sizes of PLGA nanoparticles with narrow size distributions. The newly developed PLGA nanoparticles could be readily modified with hydrophilic biomaterials on their surface and entrap hydrophobic drugs into their interiors. The encapsulation of FITC inside PLGA nanoparticles displayed a controlled release of drug system. The surfaces of the FITC entrapped PLGA nanoparticles were conjugated with quantum dots to serve as bimodal imaging probes. For nuclear transport, combination of nuclear localization signal (NLS) and PLGA nanoparticles, PLGA nanoparticles could successfully enter into HeLa cells nuclei. From tissue uptake results, PLGA nanoparticles had more uptaken by brain and liver than other tissues. The iron oxide nanoparticles-conjugated PLGA nanoparticle showed high efficiency of relaxivities r2 and could be used as the powerful magnetic resonance imaging (MRI) agents.

原文English
頁(從 - 到)2104-2112
頁數9
期刊Biomaterials
29
發行號13
DOIs
出版狀態Published - 2008 五月 1

指紋

Polyglactin 910
Nanoparticles
Fluorescein-5-isothiocyanate
Tissue
Imaging techniques
polylactic acid-polyglycolic acid copolymer
Quantum Dots
Nuclear Localization Signals
Cell Nucleus Active Transport
Biocompatible Materials
Magnetic resonance
Cell Nucleus
Microspheres
Iron oxides
HeLa Cells
Encapsulation
Biomaterials
Pharmaceutical Preparations
Liver
Semiconductor quantum dots

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

引用此文

Cheng, Fong Yu ; Wang, Saprina Ping Hsien ; Su, Chio Hao ; Tsai, Tsung Liu ; Wu, Ping Ching ; Shieh, Dar Bin ; Chen, Jyh Horng ; Hsieh, Patrick Ching Ho ; Yeh, Chen Sheng. / Stabilizer-free poly(lactide-co-glycolide) nanoparticles for multimodal biomedical probes. 於: Biomaterials. 2008 ; 卷 29, 編號 13. 頁 2104-2112.
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Stabilizer-free poly(lactide-co-glycolide) nanoparticles for multimodal biomedical probes. / Cheng, Fong Yu; Wang, Saprina Ping Hsien; Su, Chio Hao; Tsai, Tsung Liu; Wu, Ping Ching; Shieh, Dar Bin; Chen, Jyh Horng; Hsieh, Patrick Ching Ho; Yeh, Chen Sheng.

於: Biomaterials, 卷 29, 編號 13, 01.05.2008, p. 2104-2112.

研究成果: Article

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