Stable isotope dimethyl labelling for quantitative proteomics and beyond

Jue Liang Hsu, Shu Hui Chen

研究成果: Review article同行評審

18 引文 斯高帕斯(Scopus)

摘要

Stable-isotope reductive dimethylation, a costeffective, simple, robust, reliable and easy-tomultiplex labelling method, is widely applied to quantitative proteomics using liquid chromatography-mass spectrometry. This review focuses on biological applications of stable-isotope dimethyl labelling for a large-scale comparative analysis of protein expression and post-translational modifications based on its unique properties of the labelling chemistry. Some other applications of the labelling method for sample preparation and mass spectrometry-based protein identification and characterization are also summarized.

原文English
文章編號20150364
期刊Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences
374
發行號2079
DOIs
出版狀態Published - 2016 十月 28

All Science Journal Classification (ASJC) codes

  • Mathematics(all)
  • Engineering(all)
  • Physics and Astronomy(all)

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