Store-Operated Ca2+ entry in tumor progression: From molecular mechanisms to clinical implications

Yih Fung Chen, Peng Chan Lin, Yu Min Yeh, Li Hsien Chen, Meng Ru Shen

研究成果: Review article同行評審

18 引文 斯高帕斯(Scopus)

摘要

The remodeling of Ca2+ homeostasis has been implicated as a critical event in driving malignant phenotypes, such as tumor cell proliferation, motility, and metastasis. Store-operated Ca2+ entry (SOCE) that is elicited by the depletion of the endoplasmic reticulum (ER) Ca2+ stores constitutes the major Ca2+ influx pathways in most nonexcitable cells. Functional coupling between the plasma membrane Orai channels and ER Ca2+-sensing STIM proteins regulates SOCE activation. Previous studies in the human breast, cervical, and other cancer types have shown the functional significance of STIM/Orai-dependent Ca2+ signals in cancer development and progression. This article reviews the information on the regulatory mechanisms of STIM- and Orai-dependent SOCE pathways in the malignant characteristics of cancer, such as proliferation, resistance, migration, invasion, and metastasis. The recent investigations focusing on the emerging importance of SOCE in the cells of the tumor microenvironment, such as tumor angiogenesis and antitumor immunity, are also reviewed. The clinical implications as cancer therapeutics are discussed.

原文English
文章編號899
期刊Cancers
11
發行號7
DOIs
出版狀態Published - 2019 七月

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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