Striatal dopamine D 2/3 receptors in medication-naïve schizophrenia: an [123I] IBZM SPECT study

Kao Chin Chen, Yen Kuang Yang, Oliver D. Howes, I. Hui Lee, Tzung Lieh Yeh, Nan Tsing Chiu, Po See Chen, Anthony S. David, Elvira Bramon

研究成果: Article同行評審

2 引文 斯高帕斯(Scopus)


Background: The hyper-function of the striatal dopamine system has been suggested to underlie key pathophysiological mechanisms in schizophrenia. Moreover, patients have been observed to present a significant elevation of dopamine receptor availability compared to healthy controls. Although it is difficult to measure dopamine levels directly in humans, neurochemical imaging techniques such as single-photon emission computed tomography (SPECT) provide indirect indices of in vivo dopamine synthesis and release, and putative synaptic levels. Methods: We focused on the role of dopamine postsynaptic regulation using [123I] iodobenzamide (IBZM) SPECT. We compared D2/3 receptor availability between 53 healthy controls and 21 medication-naive patients with recent-onset schizophrenia. Result: The mean specific striatal binding showed no significant difference between patients and controls (estimated difference = 0.001; 95% CI -0.11 to 0.11; F = 0.00, df = 1, 69; p = 0.99). There was a highly significant effect of age whereby IBZM binding declined with advancing age [estimated change per decade of age = -0.01(binding ratio); 95% CI -0.01 to -0.004; F = 11.5, df = 1, 69; p = 0.001]. No significant correlations were found between the mean specific striatal binding and psychopathological or cognitive rating scores. Conclusions: Medication-naïve patients with recent-onset schizophrenia have similar D2/3 receptor availability to healthy controls. We suggest that, rather than focusing exclusively on postsynaptic receptors, future treatments should target the presynaptic control of dopamine synthesis and release.

頁(從 - 到)3251-3259
期刊Psychological Medicine
出版狀態Published - 2022 10月 8

All Science Journal Classification (ASJC) codes

  • 應用心理學
  • 精神病學和心理健康


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