Striatal dopamine transporter availability in drug-naive patients with schizophrenia: A case-control SPECT study with [99mTc]-TRODAT-1 and a meta-analysis

Kao Chin Chen, Yen Kuang Yang, Oliver Howes, I. Hui Lee, Sabine Landau, Tzung Lieh Yeh, Nan Tsing Chiu, Po See Chen, Ru Band Lu, Anthony S. David, Elvira Bramon

研究成果: Article同行評審

27 引文 斯高帕斯(Scopus)

摘要

Central dopaminergic hyperactivity has been one of the main hypotheses of the pathophysiology of schizophrenia since the 1970s. Excess dopamine (DA) neurotransmission in the striatum is hypothesized to alter the processing of information and result in psychotic symptoms in schizophrenia. Single photon emission computerized tomography (SPECT) provides in vivo indices of DA neurotransmission. Our study aimed to compare dopamine transporter (DAT) availability between drug-naive patients with schizophrenia and controls using SPECT. DAT availability through [99mTc]-TRODAT-1 SPECT was compared between 47 drug-naive patients with recent-onset schizophrenia and 112 healthy controls. We also conducted a random-effects meta-analysis of the available literature synthesizing the results of 6 comparable published articles as well as our current data. The mean specific striatal binding showed a statistical trend for a reduction among the patients compared with controls (estimated difference = 0.071; 95% CI-0.01, 0.15; P =. 08). There was an effect of gender, whereby females had a higher ratio of specific striatal binding than males. Age was negatively correlated with the ratio of specific striatal binding, both in patients and controls. The meta-analysis provided a pooled standardized effect size (Cohen's d) of-0.07 (95% CI-0.31, 0.18; P =. 60) for the patient vs control comparison in TRODAT binding, with no evidence of heterogeneity between studies or publication bias. Our findings suggest that striatal DAT levels are not altered in the early stages of schizophrenia before medication is introduced. We identified gender differences and aging effects that could have significance for future studies.

原文English
頁(從 - 到)378-386
頁數9
期刊Schizophrenia bulletin
39
發行號2
DOIs
出版狀態Published - 2013 3月

All Science Journal Classification (ASJC) codes

  • 精神病學和心理健康

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