Structural Definition of a Unique Neutralization Epitope on the Receptor-Binding Domain of MERS-CoV Spike Glycoprotein

Senyan Zhang, Panpan Zhou, Pengfei Wang, Yangyang Li, Liwei Jiang, Wenxu Jia, Han Wang, Angela Fan, Dongli Wang, Xuanling Shi, Xianyang Fang, Michal Hammel, Shuying Wang, Xinquan Wang, Linqi Zhang

研究成果: Article同行評審

31 引文 斯高帕斯(Scopus)

摘要

Zhang et al. report the structural and functional analysis of the potent MERS-CoV neutralizing antibody MERS-4. MERS-4 recognizes a unique epitope and indirectly disrupts interaction between the receptor binding domain and the receptor DPP4. This mechanism provides a valuable addition for the combined use of antibodies against MERS-CoV infection.

原文English
頁(從 - 到)441-452
頁數12
期刊Cell Reports
24
發行號2
DOIs
出版狀態Published - 2018 七月 10

All Science Journal Classification (ASJC) codes

  • 生物化學、遺傳與分子生物學 (全部)

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