Structure-activity and crystallographic analysis of benzophenone derivatives - The potential anticancer agents

Hsing Pang Hsieh, Jing Ping Liou, Ying Ting Lin, Neeraj Mahindroo, Jang Yang Chang, Yung Ning Yang, Shuenn Shing Chern, Uan Kang Tan, Chun Wei Chang, Tung Wei Chen, Chi Hung Lin, Ying Ying Chang, Chiung Chiu Wang

研究成果: Article同行評審

76 引文 斯高帕斯(Scopus)

摘要

Compounds 1-5, structurally related to combretastatin A-4 showed excellent cytotoxic activities against a panel of human cancer cell lines including multi-drug resistant cell lines. The X-ray three-dimensional structural analysis shows that proton donor in B ring may be required for cytotoxic activity, with intermolecular hydrogen bonding playing an important role.

原文English
頁(從 - 到)101-105
頁數5
期刊Bioorganic and Medicinal Chemistry Letters
13
發行號1
DOIs
出版狀態Published - 2003 一月 6

All Science Journal Classification (ASJC) codes

  • 生物化學
  • 分子醫學
  • 分子生物學
  • 藥學科學
  • 藥物發現
  • 臨床生物化學
  • 有機化學

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