Structure-activity relationships of chalcone analogs as potential inhibitors of ADP- and collagen-induced platelet aggregation

M. Vijaya Bhaskar Reddy, Wei Jern Tsai, Keduo Qian, Kuo Hsiung Lee, Tian Shung Wu

研究成果: Article同行評審

15 引文 斯高帕斯(Scopus)

摘要

In an effort to develop potent antiplatelet agents, 12 O-prenylated (2-13) and 10 O-allylated (14-23) chalcones were synthesized and screened for in vitro inhibitory effects on aggregation of washed rabbit platelets induced by ADP (20 μM) and collagen (10 μg/mL). In addition, the platelet aggregation activity of previously synthesized Mannich bases of heterocyclic chalcones (MBHC) (24-62) was evaluated. The preliminary structure-activity relationships suggested that the antiplatelet activity was governed to a great extent by the presence of a pyridyl ring-B and a hydroxy group at position C-3′ in ring-A of the MBHC templates.

原文English
頁(從 - 到)7711-7719
頁數9
期刊Bioorganic and Medicinal Chemistry
19
發行號24
DOIs
出版狀態Published - 2011 12月 15

All Science Journal Classification (ASJC) codes

  • 生物化學
  • 分子醫學
  • 分子生物學
  • 藥學科學
  • 藥物發現
  • 臨床生物化學
  • 有機化學

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